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  3. Profiling of humoral immune responses to norovirus in children across Europe.
 

Profiling of humoral immune responses to norovirus in children across Europe.

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BORIS DOI
10.48350/172339
Date of Publication
August 22, 2022
Publication Type
Article
Division/Institute

Institut für Virologi...

Author
Villabruna, Nele
Izquierdo-Lara, Ray W
Schapendonk, Claudia M E
de Bruin, Erwin
Chandler, Felicity
Tran, Thi Nhu Thaoorcid-logo
Institut für Virologie und Immunologie (IVI)
Westerhuis, Brenda M
van Beek, Janko
Sigfrid, Louise
Giaquinto, Carlo
Goossens, Herman
Bielicki, Julia A
Kohns Vasconcelos, Malte
Fraaij, Pieter L A
Koopmans, Marion P G
de Graaf, Miranda
Subject(s)

600 - Technology::630...

Series
Scientific Reports
ISSN or ISBN (if monograph)
2045-2322
Publisher
Nature Publishing Group
Language
English
Publisher DOI
10.1038/s41598-022-18383-6
PubMed ID
35995986
Description
Norovirus is a leading cause of epidemic acute gastroenteritis. More than 30 genotypes circulate in humans, some are common, and others are only sporadically detected. Here, we investigated whether serology can be used to determine which genotypes infect children. We established a multiplex protein microarray with structural and non-structural norovirus antigens that allowed simultaneous antibody testing against 30 human GI and GII genotypes. Antibody responses of sera obtained from 287 children aged < 1 month to 5.5 years were profiled. Most specific IgG and IgA responses were directed against the GII.2, GII.3, GII.4, and GII.6 capsid genotypes. While we detected antibody responses against rare genotypes, we found no evidence for wide circulation. We also detected genotype-specific antibodies against the non-structural proteins p48 and p22 in sera of older children. In this study, we show the age-dependent antibody responses to a broad range of norovirus capsid and polymerase genotypes, which will aid in the development of vaccines.
Handle
https://boris-portal.unibe.ch/handle/20.500.12422/86984
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s41598-022-18383-6.pdftextAdobe PDF3.42 MBAttribution (CC BY 4.0)publishedOpen
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