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Novel formulations of oral bisphosphonates in the treatment of osteoporosis.

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dc.contributor.authorFuggle, Nicholas
dc.contributor.authorAl-Daghri, Nasser
dc.contributor.authorBock, Oliver
dc.contributor.authorBranco, Jaime
dc.contributor.authorBruyère, Olivier
dc.contributor.authorCasado, Enrique
dc.contributor.authorCavalier, Etienne
dc.contributor.authorCortet, Bernard
dc.contributor.authorde Wit, Maarten
dc.contributor.authorGiusti, Andrea
dc.contributor.authorHalbout, Philippe
dc.contributor.authorHarvey, Nicholas C
dc.contributor.authorHiligsmann, Mickaël
dc.contributor.authorKaufman, Jean-Marc
dc.contributor.authorKurth, Andreas
dc.contributor.authorMaggi, Stefania
dc.contributor.authorMatijevic, Radmila
dc.contributor.authorMinisola, Salvatore
dc.contributor.authorPalacios, Santiago
dc.contributor.authorRadermecker, Régis Pierre
dc.contributor.authorThomasius, Friederike
dc.contributor.authorTuzun, Sansin
dc.contributor.authorVeronese, Nicola
dc.contributor.authorKanis, John A
dc.contributor.authorReginster, Jean-Yves
dc.contributor.authorRizzoli, René
dc.contributor.authorCooper, Cyrus
dc.date.accessioned2024-10-11T17:32:49Z
dc.date.available2024-10-11T17:32:49Z
dc.date.issued2022-11
dc.description.abstractOral bisphosphonates are a key intervention in the treatment of osteoporosis and in reducing the risk of fragility fractures. Their use is supported by over 3 decades of evidence; however, patient adherence to oral bisphosphonates remains poor in part due to complex dosing instructions and adverse events, including upper gastrointestinal symptoms. This problem has led to the development of novel oral bisphosphonate formulations. Buffered, effervescent alendronate is dissolved in water and so seeks to reduce upper gastro-intestinal adverse events, and gastro-resistant risedronate aims to reduce the complexity of dosing procedure (e.g. fasting prior to consumption) whilst still maintaining the efficacy of fracture risk reduction. Clinical trials and real-world data have been employed to demonstrate some benefits in terms of reduced upper gastro-intestinal adverse events, adherence, persistence and health economic outcomes. This report describes the result of an ESCEO (European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis) expert working group, which explores where oral bisphosphonates sit in current clinical practice guidelines, review their risk-benefit profile and the consequences of poor adherence before exploring novel oral bisphosphonate formulations and their potential clinical and health economic impact. Further research is required but there are signs that these novel, oral bisphosphonate formulations may lead to improved tolerance of oral bisphosphonates and thus, improved adherence and fracture outcomes.
dc.description.numberOfPages10
dc.description.sponsorshipUniversitätspoliklinik für Osteoporose
dc.identifier.doi10.48350/174517
dc.identifier.pmid36331798
dc.identifier.publisherDOI10.1007/s40520-022-02272-z
dc.identifier.urihttps://boris-portal.unibe.ch/handle/20.500.12422/88685
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofAging clinical and experimental research
dc.relation.issn1720-8319
dc.relation.organizationDCD5A442BA4BE17DE0405C82790C4DE2
dc.relation.urlhttps://boris.unibe.ch/176787/
dc.subjectAlendronate Bisphosphonates Fragility fracture Osteoporosis Risedronate Therapy
dc.subject.ddc600 - Technology::610 - Medicine & health
dc.titleNovel formulations of oral bisphosphonates in the treatment of osteoporosis.
dc.typearticle
dspace.entity.typePublication
dspace.file.typetext
oaire.citation.endPage2634
oaire.citation.issue11
oaire.citation.startPage2625
oaire.citation.volume34
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unibe.date.licenseChanged2022-11-07 13:32:54
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