Elevated CSF histamine levels in multiple sclerosis patients.
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BORIS DOI
Publisher DOI
PubMed ID
23659456
Description
BACKGROUND
Histamine is an ubiquitous inflammatory mediator of numerous physiological processes. Histamine and its receptors have been implicated in multiple sclerosis (MS) disease pathogenesis. We prospectively enrolled 36 MS patients and 19 age and gender-matched healthy volunteers for cerebrospinal fluid (CSF) histamine analysis.
FINDINGS
CSF HISTAMINE LEVELS IN MS PATIENT SAMPLES WERE SIGNIFICANTLY HIGHER (MEDIAN: 35.6 pg/ml) than in controls (median: 5.5 pg/ml; Beta = 0.525, p < 0.001). In addition, histamine increased with age (Pearson's correlation, p < 0.003).
CONCLUSIONS
Histamine may be an important factor for both the initiation and maintenance of chronic inflammatory diseases of the central nervous system. Our observation encourages a deeper investigation of the role of histamine in MS.
Histamine is an ubiquitous inflammatory mediator of numerous physiological processes. Histamine and its receptors have been implicated in multiple sclerosis (MS) disease pathogenesis. We prospectively enrolled 36 MS patients and 19 age and gender-matched healthy volunteers for cerebrospinal fluid (CSF) histamine analysis.
FINDINGS
CSF HISTAMINE LEVELS IN MS PATIENT SAMPLES WERE SIGNIFICANTLY HIGHER (MEDIAN: 35.6 pg/ml) than in controls (median: 5.5 pg/ml; Beta = 0.525, p < 0.001). In addition, histamine increased with age (Pearson's correlation, p < 0.003).
CONCLUSIONS
Histamine may be an important factor for both the initiation and maintenance of chronic inflammatory diseases of the central nervous system. Our observation encourages a deeper investigation of the role of histamine in MS.
Date of Publication
2013
Publication Type
Article
Subject(s)
Keyword(s)
Multiple sclerosis
•
Histamine
•
Histamine receptors
•
CSF
•
Granulocyte-macrophage colony-stimulating factor
•
Chronic inflammatory diseases
Language(s)
en
Contributor(s)
Kallweit, Ulf | |
Aritake, Kosuke | |
Blumenthal, Stephan | |
Hayaishi, Osamu | |
Linnebank, Michael | |
Baumann, Christian R. | |
Urade, Yoshihiro |
Additional Credits
Series
Fluids and barriers of the CNS
Publisher
BioMed Central
ISSN
2045-8118
Access(Rights)
open.access