Publication:
Impact of Aneurysm Multiplicity on Treatment and Outcome After Aneurysmal Subarachnoid Hemorrhage.

cris.virtualsource.author-orciddb4c0af6-174f-44b4-b1bb-25ca157774bc
cris.virtualsource.author-orcid9accaa6f-eaf7-4d2c-8c5c-273a4a08457b
cris.virtualsource.author-orcid1d1add55-4917-49a3-96d7-ddbe67e8965c
datacite.rightsrestricted
dc.contributor.authorRoethlisberger, Michel
dc.contributor.authorAchermann, Rita
dc.contributor.authorBawarjan, Schatlo
dc.contributor.authorStienen, Martin N
dc.contributor.authorFung, Christian
dc.contributor.authorD'Alonzo, Donato
dc.contributor.authorMaldaner, Nicolai
dc.contributor.authorFerrari, Andrea
dc.contributor.authorCorniola, Marco V
dc.contributor.authorSchöni, Daniel Stephan
dc.contributor.authorGoldberg, Johannes
dc.contributor.authorValsecchi, Daniele
dc.contributor.authorRobert, Thomas
dc.contributor.authorMaduri, Rodolfo
dc.contributor.authorSeule, Martin A
dc.contributor.authorBurkhardt, Jan-Karl
dc.contributor.authorMarbacher, Serge
dc.contributor.authorBijlenga, Philippe
dc.contributor.authorBlackham, Kristine A
dc.contributor.authorBucher, Heiner C
dc.contributor.authorMariani, Luigi
dc.contributor.authorGuzman, Raphael
dc.contributor.authorZumofen, Daniel W
dc.date.accessioned2024-10-07T16:52:39Z
dc.date.available2024-10-07T16:52:39Z
dc.date.issued2019-06-01
dc.description.abstractBACKGROUND One-third of patients with aneurysmal subarachnoid hemorrhage (aSAH) have multiple intracranial aneurysms (MIA). OBJECTIVE To determine the predictors of outcome in aSAH patients with MIA compared to aSAH patients with a single intracranial aneurysm (SIA). METHODS The Swiss Study of Subarachnoid Hemorrhage dataset 2009-2014 was used to evaluate outcome in aSAH patients with MIA compared to patients with SIA with the aid of descriptive and multivariate regression analysis. The primary endpoints of this cohort study were presence of new stroke on computed tomography (CT) after aneurysm treatment, and presence of stroke on CT prior to discharge. The secondary endpoints were the clinical and the functional status, and the overall mortality at discharge and at 1 yr. RESULTS Among 1689 consecutive patients, 467 had MIA (prevalence: 26.4%). The incidence of stroke was higher in the MIA than in the SIA group, both after aneurysm treatment (19.3% vs 15.1%) and at discharge (24% vs 21.4%). However, the 95% confidence interval (CI) for the corresponding odds ratio (OR) in our multivariate model included 1, indicating that the detected trends did not reach statistical significance. As for the secondary endpoints, aneurysm multiplicity was found to be an independent, statistically significant predictor for occurrence of a new focal neurological deficit between admission and discharge (OR 1.40, 95% CI 1.08-1.81). Yet, the MIA and SIA groups did not differ in terms of either functional outcome or overall survival. CONCLUSION aSAH patients with MIA have a higher short-term morbidity than patients with SIA. This excess morbidity does not worsen the functional outcome or lower overall survival.
dc.description.sponsorshipUniversitätsklinik für Neurochirurgie
dc.identifier.doi10.7892/boris.123024
dc.identifier.pmid30113674
dc.identifier.publisherDOI10.1093/neuros/nyy331
dc.identifier.urihttps://boris-portal.unibe.ch/handle/20.500.12422/61916
dc.language.isoen
dc.publisherOxford University Press
dc.relation.ispartofNeurosurgery
dc.relation.issn1524-4040
dc.relation.organizationDCD5A442C057E17DE0405C82790C4DE2
dc.subject.ddc600 - Technology::610 - Medicine & health
dc.titleImpact of Aneurysm Multiplicity on Treatment and Outcome After Aneurysmal Subarachnoid Hemorrhage.
dc.typearticle
dspace.entity.typePublication
dspace.file.typetext
oaire.citation.endPageE344
oaire.citation.issue6
oaire.citation.startPageE334
oaire.citation.volume84
oairecerif.author.affiliationUniversitätsklinik für Neurochirurgie
oairecerif.author.affiliationUniversitätsklinik für Neurochirurgie
oairecerif.author.affiliationUniversitätsklinik für Neurochirurgie
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unibe.date.licenseChanged2019-10-22 20:02:12
unibe.description.ispublishedpub
unibe.eprints.legacyId123024
unibe.refereedtrue
unibe.subtype.articlejournal

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