Development of Late-Onset Preeclampsia in Association with Road Densities as a Proxy for Traffic-Related Air Pollution.
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BORIS DOI
Publisher DOI
PubMed ID
26088708
Description
INTRODUCTION
Previous epidemiological studies indicate an association between maternal exposure to air pollution and an increased risk of hypertensive disorders in pregnancy. We analyzed the association between the occurrence of mild/severe and early-/late-onset preeclampsia (PE) and traffic-related air pollution (TRAP).
MATERIALS AND METHODS
Based on retrospective data, 50 pregnant women with PE were selected and matched with a control group of healthy pregnant women according to their age, parity, and number of fetuses. The total length of major roads around the women's home within a radius of 100, 200, 300, and 500 m and the distances from the domicile to the nearest 'first class' main road and freeway were used as a proxy indicator of TRAP. We compared a PE subgroup and control group in terms of their exposure to TRAP.
RESULTS
Late-onset PE cases showed a significantly higher occurrence with density of major roads within a radius of 100-300 m compared to early onset cases (p = 0.006; 0.02; 0.04). In addition, a significantly shorter distance to the nearest 'first class' main road was observed in late-onset PE cases (p = 0.0078).
CONCLUSIONS
Exposure to TRAP during pregnancy was associated with an increased risk for the development of late-onset PE.
Previous epidemiological studies indicate an association between maternal exposure to air pollution and an increased risk of hypertensive disorders in pregnancy. We analyzed the association between the occurrence of mild/severe and early-/late-onset preeclampsia (PE) and traffic-related air pollution (TRAP).
MATERIALS AND METHODS
Based on retrospective data, 50 pregnant women with PE were selected and matched with a control group of healthy pregnant women according to their age, parity, and number of fetuses. The total length of major roads around the women's home within a radius of 100, 200, 300, and 500 m and the distances from the domicile to the nearest 'first class' main road and freeway were used as a proxy indicator of TRAP. We compared a PE subgroup and control group in terms of their exposure to TRAP.
RESULTS
Late-onset PE cases showed a significantly higher occurrence with density of major roads within a radius of 100-300 m compared to early onset cases (p = 0.006; 0.02; 0.04). In addition, a significantly shorter distance to the nearest 'first class' main road was observed in late-onset PE cases (p = 0.0078).
CONCLUSIONS
Exposure to TRAP during pregnancy was associated with an increased risk for the development of late-onset PE.
Date of Publication
2016
Publication Type
Article
Subject(s)
Language(s)
en
Contributor(s)
Wu, Meng | |
Ries, Jean-Jacques | |
Vogt, Deborah | |
Hahn, Sinuhe | |
Hoesli, Irene |
Additional Credits
Series
Fetal diagnosis and therapy
Publisher
Karger
ISSN
1015-3837
Access(Rights)
open.access