Glutathione peroxidase overexpression causes aberrant ERK activation in neonatal mouse cortex after hypoxic preconditioning

Publisher DOI
PubMed ID
23007029
Description
Preconditioning of neonatal mice with nonlethal hypoxia (HPC) protects the brain from hypoxic-ischemic (HI) injury. Overexpression of human glutathione peroxidase 1 (GPx1), which normally protects the developing murine brain from HI injury, reverses HPC protection, suggesting that a certain threshold of hydrogen peroxide concentration is required for activation of HPC signaling.
Date of Publication
2012
Publication Type
Article
Language(s)
en
Contributor(s)
Autheman, Delphine
Sheldon, R Ann
Chaudhuri, Nondini
von Arx, Sebastian
Siegenthaler, Corinne
Ferriero, Donna M
Additional Credits
Series
Pediatric research
Publisher
Nature Publishing Group
ISSN
0031-3998
Access(Rights)
metadata.only
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