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  3. Pediatric Patients with Eosinophilic Esophagitis and Their Parents Identify Symptoms as the Most Important Treatment Outcome.
 

Pediatric Patients with Eosinophilic Esophagitis and Their Parents Identify Symptoms as the Most Important Treatment Outcome.

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BORIS DOI
10.48350/193927
Date of Publication
March 6, 2024
Publication Type
Article
Division/Institute

Institut für Sozial- ...

Universitätsklinik fü...

Author
von Graffenried, Thea
Safroneeva, Ekaterina
Institut für Sozial- und Präventivmedizin (ISPM)
Braegger, Christian
Ezri, Jessica
Garzoni, Luca
Giroud Rivier, Alexa
Greuter, Thomas
Köhler, Henrik
McLin, Valerie A
Marx, George
Müller, Pascal
Petit, Laetitia Marie
Schibli, Susanne
Universitätsklinik für Kinderheilkunde
Sokollik, Christianeorcid-logo
Universitätsklinik für Kinderheilkunde
Tempia-Caliera, Michela
Zwahlen, Marcelorcid-logo
Institut für Sozial- und Präventivmedizin (ISPM)
Schoepfer, Alain M
Nydegger, Andreas
Subject(s)

600 - Technology::610...

300 - Social sciences...

Series
International archives of allergy and immunology
ISSN or ISBN (if monograph)
1018-2438
Publisher
Karger
Language
English
Publisher DOI
10.1159/000535242
PubMed ID
38447548
Uncontrolled Keywords

Core outcome set Endp...

Description
INTRODUCTION

Given the lack of data, we aimed to explore which therapeutic endpoints pediatric patients with eosinophilic esophagitis (EoE) and their parents consider to be relevant.

METHODS

We created an educational brochure on EoE and a questionnaire, both of which were content-validated by pediatric patients and parents. Validated documents were sent to 112 patients and parents. They ranked the importance (5 levels) of short (during next 3 months) and long-term (≥1 year) treatment effect on symptoms, quality of life, endoscopic inflammation, stricture formation, histological inflammation, and fibrosis.

RESULTS

A total of 45 parents and 30 pediatric patients ≥11 years completed the questionnaires. Pediatric patients identified improvement in the following domains as most important in the short- and long-term, respectively: symptoms (73% vs. 77%), QoL (53% vs. 57%), histologic inflammation (47% vs. 50%), histologic fibrosis (40% vs. 33%), endoscopic inflammation (47% vs. 40%), and strictures (33% vs. 40%). Parents of children ≥11 years old classified improvement in the following domains as most important in the short- and long-term, respectively: symptoms (70% vs. 83%), QoL (63% vs. 80%), histologic inflammation (67% vs. 77%), histologic fibrosis (47% vs. 63%), endoscopic inflammation (77% vs. 80%), and strictures (40% vs. 53%). Agreement between caregiver and children on the short-term importance of treatment outcomes was as follows: symptoms (77%), QoL (40%), histologic inflammation and fibrosis (47% and 43%), endoscopic inflammation and strictures (50% and 40%).

CONCLUSION

Pediatric patients and parents attributed most importance to improvement in symptoms and QoL. Agreement between parents and patients regarding therapy goals is limited.
Handle
https://boris-portal.unibe.ch/handle/20.500.12422/175263
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vonGraffenried_IntArchAllergyImmunol_2024.pdftextAdobe PDF376.39 KBpublished
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