Clinical, pathologic, and immunohistochemical prognostic factors in dogs with thyroid carcinoma.
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BORIS DOI
Publisher DOI
PubMed ID
25252127
Description
BACKGROUND
Prognostic markers for dogs with thyroid tumors are limited.
HYPOTHESIS/OBJECTIVES
To identify clinical, pathologic, and immunohistochemical prognostic factors for dogs with thyroid tumors.
ANIMALS
Seventy dogs with thyroid neoplasia.
METHODS
Retrospective study. Dogs with thyroid neoplasia were included when follow-up information and formalin-fixed paraffin-embedded tumor samples were available. Immunohistochemistry (IHC) was performed for thyroglobulin, calcitonin, Ki-67, and E-cadherin. Correlation of tumor variables (diameter, volume, localization, scintigraphic uptake, thyroid function, IHC) with local invasiveness and metastatic disease was performed on all tumor samples. Forty-four dogs treated by thyroidectomy were included in a survival analysis.
RESULTS
Fifty dogs (71%) had differentiated follicular cell thyroid carcinoma (dFTC) and 20 (29%) had medullary thyroid carcinoma (MTC). At diagnosis, tumor diameter (P = .007; P = .038), tumor volume (P = .020), tumor fixation (P = .002), ectopic location (P = .002), follicular cell origin (P = .044), and Ki-67 (P = .038) were positively associated with local invasiveness; tumor diameter (P = .002), tumor volume (P = .023), and bilateral location (P = .012) were positively associated with presence of distant metastases. Forty-four dogs (28 dFTC, 16 MTC; stage I-III) underwent thyroidectomy. Outcome was comparable between dogs with dFTC and MTC. Macroscopic (P = .007) and histologic (P = .046) vascular invasion were independent negative predictors for disease-free survival. Although time to presentation, histologic vascular invasion and Ki-67 were negatively associated with time to metastases, and time to presentation was negatively associated with time to recurrence, no independent predictors were found. E-cadherin expression was not associated with outcome.
CONCLUSIONS AND CLINICAL IMPORTANCE
Prognostic factors have been identified that provide relevant information for owners and clinicians.
Prognostic markers for dogs with thyroid tumors are limited.
HYPOTHESIS/OBJECTIVES
To identify clinical, pathologic, and immunohistochemical prognostic factors for dogs with thyroid tumors.
ANIMALS
Seventy dogs with thyroid neoplasia.
METHODS
Retrospective study. Dogs with thyroid neoplasia were included when follow-up information and formalin-fixed paraffin-embedded tumor samples were available. Immunohistochemistry (IHC) was performed for thyroglobulin, calcitonin, Ki-67, and E-cadherin. Correlation of tumor variables (diameter, volume, localization, scintigraphic uptake, thyroid function, IHC) with local invasiveness and metastatic disease was performed on all tumor samples. Forty-four dogs treated by thyroidectomy were included in a survival analysis.
RESULTS
Fifty dogs (71%) had differentiated follicular cell thyroid carcinoma (dFTC) and 20 (29%) had medullary thyroid carcinoma (MTC). At diagnosis, tumor diameter (P = .007; P = .038), tumor volume (P = .020), tumor fixation (P = .002), ectopic location (P = .002), follicular cell origin (P = .044), and Ki-67 (P = .038) were positively associated with local invasiveness; tumor diameter (P = .002), tumor volume (P = .023), and bilateral location (P = .012) were positively associated with presence of distant metastases. Forty-four dogs (28 dFTC, 16 MTC; stage I-III) underwent thyroidectomy. Outcome was comparable between dogs with dFTC and MTC. Macroscopic (P = .007) and histologic (P = .046) vascular invasion were independent negative predictors for disease-free survival. Although time to presentation, histologic vascular invasion and Ki-67 were negatively associated with time to metastases, and time to presentation was negatively associated with time to recurrence, no independent predictors were found. E-cadherin expression was not associated with outcome.
CONCLUSIONS AND CLINICAL IMPORTANCE
Prognostic factors have been identified that provide relevant information for owners and clinicians.
Date of Publication
2014-11
Publication Type
Article
Subject(s)
Keyword(s)
Calcitonin
•
E-cadherin
•
Follicular
•
Ki-67
•
Medullary
Language(s)
en
Contributor(s)
Ducatelle, R | |
Rutteman, G | |
Kooistra, H S | |
Duchateau, L | |
de Rooster, H | |
Peremans, K | |
Daminet, S |
Additional Credits
Series
Journal of veterinary internal medicine
Publisher
Wiley-Blackwell
ISSN
0891-6640
Access(Rights)
restricted