Publication:
CXCL14 Chemokine Exacerbates Acute Viral Hepatitis in Coronavirus MHV-Infected Mice and Is Associated With Human Acute Viral Hepatitis.

cris.virtual.author-orcid0000-0002-2049-7769
cris.virtualsource.author-orcid6e4369cc-4bf6-4d77-a3f8-2c9721724224
cris.virtualsource.author-orcid350d8e59-fb26-4987-815c-7706769a76f1
datacite.rightsopen.access
dc.contributor.authorDevisme, Christelle
dc.contributor.authorPiquet-Pellorce, Claire
dc.contributor.authorChalin, Arnaud
dc.contributor.authorLefevre, Benjamin
dc.contributor.authorPronier, Charlotte
dc.contributor.authorThibault, Vincent
dc.contributor.authorLe Seyec, Jacques
dc.contributor.authorRaguénès-Nicol, Céline
dc.contributor.authorBenarafa, Charaf
dc.contributor.authorSamson, Michel
dc.date.accessioned2025-07-10T07:03:20Z
dc.date.available2025-07-10T07:03:20Z
dc.date.issued2025-05-31
dc.description.abstractDeaths from viral hepatitis continue to rise around the world due to the lack of early biomarkers. We aimed here to evaluate the chemokine CXCL14, as a novel biomarker in acute viral hepatitis. We used a mouse model of acute hepatitis induced by murine hepatitis virus (MHV), a hepatotropic and lytic coronavirus, and showed that CXCL14 is overexpressed in the liver and sera of infected mice. Using primary cultures of murine and human hepatocytes, we showed that hepatocytes are the main source of CXCL14 after lytic hepatotropic virus infection and that CXCL14 expression is also induced by the pro-inflammatory cytokines IL-6 and TNFα. CXCL14 KO mice infected with MHV were partially protected and showed an attenuated antiviral immune response compared to wild-type mice. Finally, we show that CXCL14 is overexpressed in the sera of human patients infected with hepatitis viruses A, B, and E or herpes simplex virus. A positive correlation between CXCL14 and ALT levels in the sera of patients with acute herpetic hepatitis, as well as in mice models, suggests that hepatocyte lysis is necessary for the release of CXCL14. Overall, these data highlight that CXCL14 expression is associated with the occurrence of acute viral hepatitis and could be considered an alarmin and a new indicator of inflammation. CXCL14 serum levels are also associated with the severity of viral-induced liver injury.
dc.description.numberOfPages17
dc.description.sponsorshipMultidisciplinary Center for Infectious Diseases (MCID)
dc.description.sponsorshipDepartment of Infectious Diseases and Pathobiology (DIP)
dc.description.sponsorshipInstitute of Virology and Immunology
dc.identifier.doi10.48620/89349
dc.identifier.pmid40392027
dc.identifier.publisherDOI10.1096/fj.202401706R
dc.identifier.urihttps://boris-portal.unibe.ch/handle/20.500.12422/211529
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofThe FASEB Journal
dc.relation.issn1530-6860
dc.relation.issn0892-6638
dc.subjectCXCL14
dc.subjectacute viral hepatitis
dc.subjectalarmin
dc.subjectchemokine
dc.subjecthuman blood sample
dc.subjectimmune response
dc.subjectmouse animal
dc.subject.ddc600 - Technology::630 - Agriculture
dc.titleCXCL14 Chemokine Exacerbates Acute Viral Hepatitis in Coronavirus MHV-Infected Mice and Is Associated With Human Acute Viral Hepatitis.
dc.typearticle
dspace.entity.typePublication
dspace.file.typetext
oaire.citation.issue10
oaire.citation.startPagee70591
oaire.citation.volume39
oairecerif.author.affiliationInstitute of Virology and Immunology
oairecerif.author.affiliationInstitute of Virology and Immunology
unibe.additional.sponsorshipMultidisciplinary Center for Infectious Diseases (MCID)
unibe.additional.sponsorshipDepartment of Infectious Diseases and Pathobiology (DIP)
unibe.contributor.orcid0000-0002-2049-7769
unibe.contributor.roleauthor
unibe.contributor.roleauthor
unibe.description.ispublishedpub
unibe.refereedtrue
unibe.subtype.articlejournal

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