Publication:
Diabetes and Overweight/Obesity Are Independent, Nonadditive Risk Factors for In-Hospital Severity of COVID-19: An International, Multicenter Retrospective Meta-analysis.

cris.virtualsource.author-orcide21029a1-fd88-4597-8e1f-25b4dc892347
datacite.rightsrestricted
dc.contributor.authorLongmore, Danielle K
dc.contributor.authorMiller, Jessica E
dc.contributor.authorBekkering, Siroon
dc.contributor.authorSaner, Christoph
dc.contributor.authorMifsud, Edin
dc.contributor.authorZhu, Yanshan
dc.contributor.authorSaffery, Richard
dc.contributor.authorNichol, Alistair
dc.contributor.authorColditz, Graham
dc.contributor.authorShort, Kirsty R
dc.contributor.authorBurgner, David P
dc.date.accessioned2024-10-06T18:49:49Z
dc.date.available2024-10-06T18:49:49Z
dc.date.issued2021-06
dc.description.abstractOBJECTIVE Obesity is an established risk factor for severe coronavirus disease 2019 (COVID-19), but the contribution of overweight and/or diabetes remains unclear. In a multicenter, international study, we investigated if overweight, obesity, and diabetes were independently associated with COVID-19 severity and whether the BMI-associated risk was increased among those with diabetes. RESEARCH DESIGN AND METHODS We retrospectively extracted data from health care records and regional databases of hospitalized adult patients with COVID-19 from 18 sites in 11 countries. We used standardized definitions and analyses to generate site-specific estimates, modeling the odds of each outcome (supplemental oxygen/noninvasive ventilatory support, invasive mechanical ventilatory support, and in-hospital mortality) by BMI category (reference, overweight, obese), adjusting for age, sex, and prespecified comorbidities. Subgroup analysis was performed on patients with preexisting diabetes. Site-specific estimates were combined in a meta-analysis. RESULTS Among 7,244 patients (65.6% overweight/obese), those with overweight were more likely to require oxygen/noninvasive ventilatory support (random effects adjusted odds ratio [aOR], 1.44; 95% CI 1.15-1.80) and invasive mechanical ventilatory support (aOR, 1.22; 95% CI 1.03-1.46). There was no association between overweight and in-hospital mortality (aOR, 0.88; 95% CI 0.74-1.04). Similar effects were observed in patients with obesity or diabetes. In the subgroup analysis, the aOR for any outcome was not additionally increased in those with diabetes and overweight or obesity. CONCLUSIONS In adults hospitalized with COVID-19, overweight, obesity, and diabetes were associated with increased odds of requiring respiratory support but were not associated with death. In patients with diabetes, the odds of severe COVID-19 were not increased above the BMI-associated risk.
dc.description.numberOfPages10
dc.description.sponsorshipUniversitätsklinik für Kinderheilkunde
dc.identifier.doi10.48350/161516
dc.identifier.pmid33858854
dc.identifier.publisherDOI10.2337/dc20-2676
dc.identifier.urihttps://boris-portal.unibe.ch/handle/20.500.12422/57739
dc.language.isoen
dc.publisherAmerican Diabetes Association
dc.relation.ispartofDiabetes care
dc.relation.issn0149-5992
dc.relation.organizationDCD5A442BADAE17DE0405C82790C4DE2
dc.relation.organizationDCD5A442C248E17DE0405C82790C4DE2
dc.subject.ddc600 - Technology::610 - Medicine & health
dc.titleDiabetes and Overweight/Obesity Are Independent, Nonadditive Risk Factors for In-Hospital Severity of COVID-19: An International, Multicenter Retrospective Meta-analysis.
dc.typearticle
dspace.entity.typePublication
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oaire.citation.endPage1290
oaire.citation.issue6
oaire.citation.startPage1281
oaire.citation.volume44
oairecerif.author.affiliationUniversitätsklinik für Kinderheilkunde
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unibe.date.licenseChanged2021-12-07 12:59:22
unibe.description.ispublishedpub
unibe.eprints.legacyId161516
unibe.journal.abbrevTitleDIABETES CARE
unibe.refereedtrue
unibe.subtype.articlejournal

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