Publication: Frequency and impact on renal transplant outcomes of urinary tract infections due to extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella species.
cris.virtual.author-orcid | 0000-0002-7048-6590 | |
cris.virtualsource.author-orcid | 2cbd9e6a-4be4-44fa-89ad-067f82762d16 | |
cris.virtualsource.author-orcid | ad043c4b-64bc-47d8-a380-62d619be67a0 | |
datacite.rights | open.access | |
dc.contributor.author | Brune, Jakob E | |
dc.contributor.author | Dickenmann, Michael | |
dc.contributor.author | Sidler, Daniel | |
dc.contributor.author | Walti, Laura Naëmi | |
dc.contributor.author | Golshayan, Déla | |
dc.contributor.author | Manuel, Oriol | |
dc.contributor.author | Haidar, Fadi | |
dc.contributor.author | Neofytos, Dionysios | |
dc.contributor.author | Schnyder, Aurelia | |
dc.contributor.author | Boggian, Katia | |
dc.contributor.author | Mueller, Thomas F | |
dc.contributor.author | Schachtner, Thomas | |
dc.contributor.author | Khanna, Nina | |
dc.contributor.author | Schaub, Stefan | |
dc.contributor.author | Wehmeier, Caroline | |
dc.date.accessioned | 2024-10-26T17:27:38Z | |
dc.date.available | 2024-10-26T17:27:38Z | |
dc.date.issued | 2024 | |
dc.description | Collaborators "Swiss Transplant Cohort Study": Annalisa Berzigotti, Guido Stirnimann , Vanessa Banz, Guido Beldi (UVCM Department of Visceral Surgery and Medicine) | |
dc.description.abstract | BACKGROUND Enterobacterales are often responsible for urinary tract infection (UTI) in kidney transplant recipients. Among these, Escherichia coli or Klebsiella species producing extended-spectrum beta-lactamase (ESBL) are emerging. However, there are only scarce data on frequency and impact of ESBL-UTI on transplant outcomes. METHODS We investigated frequency and impact of first-year UTI events with ESBL Escherichia coli and/or Klebsiella species in a prospective multicenter cohort consisting of 1,482 kidney transplants performed between 2012 and 2017, focusing only on 389 kidney transplants having at least one UTI with Escherichia coli and/or Klebsiella species. The cohort had a median follow-up of four years. RESULTS In total, 139/825 (17%) first-year UTI events in 69/389 (18%) transplant recipients were caused by ESBL-producing strains. Both UTI phenotypes and proportion among all UTI events over time were not different compared with UTI caused by non-ESBL-producing strains. However, hospitalizations in UTI with ESBL-producing strains were more often observed (39% versus 26%, p = 0.04). Transplant recipients with first-year UTI events with an ESBL-producing strain had more frequently recurrent UTI (33% versus 18%, p = 0.02) but there was no significant difference in one-year kidney function as well as longer-term graft and patient survival between patients with and without ESBL-UTI. CONCLUSION First-year UTI events with ESBL-producing Escherichia coli and/or Klebsiella species are associated with a higher need for hospitalization but do neither impact allograft function nor allograft and patient survival. | |
dc.description.sponsorship | Universitätsklinik für Nephrologie und Hypertonie | |
dc.description.sponsorship | Universitätsklinik für Infektiologie | |
dc.identifier.doi | 10.48350/193679 | |
dc.identifier.pmid | 38426162 | |
dc.identifier.publisherDOI | 10.3389/fmed.2024.1329778 | |
dc.identifier.uri | https://boris-portal.unibe.ch/handle/20.500.12422/175071 | |
dc.language.iso | en | |
dc.publisher | Frontiers | |
dc.relation.ispartof | Frontiers in medicine | |
dc.relation.issn | 2296-858X | |
dc.relation.organization | DCD5A442BB13E17DE0405C82790C4DE2 | |
dc.relation.organization | DCD5A442BB17E17DE0405C82790C4DE2 | |
dc.subject | E. coli ESBL − extended-spectrum beta-lactamase Enterobacterales Klebsiella graft survival kidney transplantation urinary tract infection | |
dc.subject.ddc | 600 - Technology::610 - Medicine & health | |
dc.title | Frequency and impact on renal transplant outcomes of urinary tract infections due to extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella species. | |
dc.type | article | |
dspace.entity.type | Publication | |
dspace.file.type | text | |
oaire.citation.issue | 1329778 | |
oaire.citation.volume | 11 | |
oairecerif.author.affiliation | Universitätsklinik für Nephrologie und Hypertonie | |
oairecerif.author.affiliation | Universitätsklinik für Infektiologie | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.date.licenseChanged | 2024-03-05 14:41:40 | |
unibe.description.ispublished | pub | |
unibe.eprints.legacyId | 193679 | |
unibe.refereed | true | |
unibe.subtype.article | journal |
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