Publication:
Frequency and impact on renal transplant outcomes of urinary tract infections due to extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella species.

cris.virtual.author-orcid0000-0002-7048-6590
cris.virtualsource.author-orcid2cbd9e6a-4be4-44fa-89ad-067f82762d16
cris.virtualsource.author-orcidad043c4b-64bc-47d8-a380-62d619be67a0
datacite.rightsopen.access
dc.contributor.authorBrune, Jakob E
dc.contributor.authorDickenmann, Michael
dc.contributor.authorSidler, Daniel
dc.contributor.authorWalti, Laura Naëmi
dc.contributor.authorGolshayan, Déla
dc.contributor.authorManuel, Oriol
dc.contributor.authorHaidar, Fadi
dc.contributor.authorNeofytos, Dionysios
dc.contributor.authorSchnyder, Aurelia
dc.contributor.authorBoggian, Katia
dc.contributor.authorMueller, Thomas F
dc.contributor.authorSchachtner, Thomas
dc.contributor.authorKhanna, Nina
dc.contributor.authorSchaub, Stefan
dc.contributor.authorWehmeier, Caroline
dc.date.accessioned2024-10-26T17:27:38Z
dc.date.available2024-10-26T17:27:38Z
dc.date.issued2024
dc.descriptionCollaborators "Swiss Transplant Cohort Study": Annalisa Berzigotti, Guido Stirnimann , Vanessa Banz, Guido Beldi (UVCM Department of Visceral Surgery and Medicine)
dc.description.abstractBACKGROUND Enterobacterales are often responsible for urinary tract infection (UTI) in kidney transplant recipients. Among these, Escherichia coli or Klebsiella species producing extended-spectrum beta-lactamase (ESBL) are emerging. However, there are only scarce data on frequency and impact of ESBL-UTI on transplant outcomes. METHODS We investigated frequency and impact of first-year UTI events with ESBL Escherichia coli and/or Klebsiella species in a prospective multicenter cohort consisting of 1,482 kidney transplants performed between 2012 and 2017, focusing only on 389 kidney transplants having at least one UTI with Escherichia coli and/or Klebsiella species. The cohort had a median follow-up of four years. RESULTS In total, 139/825 (17%) first-year UTI events in 69/389 (18%) transplant recipients were caused by ESBL-producing strains. Both UTI phenotypes and proportion among all UTI events over time were not different compared with UTI caused by non-ESBL-producing strains. However, hospitalizations in UTI with ESBL-producing strains were more often observed (39% versus 26%, p = 0.04). Transplant recipients with first-year UTI events with an ESBL-producing strain had more frequently recurrent UTI (33% versus 18%, p = 0.02) but there was no significant difference in one-year kidney function as well as longer-term graft and patient survival between patients with and without ESBL-UTI. CONCLUSION First-year UTI events with ESBL-producing Escherichia coli and/or Klebsiella species are associated with a higher need for hospitalization but do neither impact allograft function nor allograft and patient survival.
dc.description.sponsorshipUniversitätsklinik für Nephrologie und Hypertonie
dc.description.sponsorshipUniversitätsklinik für Infektiologie
dc.identifier.doi10.48350/193679
dc.identifier.pmid38426162
dc.identifier.publisherDOI10.3389/fmed.2024.1329778
dc.identifier.urihttps://boris-portal.unibe.ch/handle/20.500.12422/175071
dc.language.isoen
dc.publisherFrontiers
dc.relation.ispartofFrontiers in medicine
dc.relation.issn2296-858X
dc.relation.organizationDCD5A442BB13E17DE0405C82790C4DE2
dc.relation.organizationDCD5A442BB17E17DE0405C82790C4DE2
dc.subjectE. coli ESBL − extended-spectrum beta-lactamase Enterobacterales Klebsiella graft survival kidney transplantation urinary tract infection
dc.subject.ddc600 - Technology::610 - Medicine & health
dc.titleFrequency and impact on renal transplant outcomes of urinary tract infections due to extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella species.
dc.typearticle
dspace.entity.typePublication
dspace.file.typetext
oaire.citation.issue1329778
oaire.citation.volume11
oairecerif.author.affiliationUniversitätsklinik für Nephrologie und Hypertonie
oairecerif.author.affiliationUniversitätsklinik für Infektiologie
unibe.contributor.rolecreator
unibe.contributor.rolecreator
unibe.contributor.rolecreator
unibe.contributor.rolecreator
unibe.contributor.rolecreator
unibe.contributor.rolecreator
unibe.contributor.rolecreator
unibe.contributor.rolecreator
unibe.contributor.rolecreator
unibe.contributor.rolecreator
unibe.contributor.rolecreator
unibe.contributor.rolecreator
unibe.contributor.rolecreator
unibe.contributor.rolecreator
unibe.contributor.rolecreator
unibe.date.licenseChanged2024-03-05 14:41:40
unibe.description.ispublishedpub
unibe.eprints.legacyId193679
unibe.refereedtrue
unibe.subtype.articlejournal

Files

Original bundle
Now showing 1 - 1 of 1
Name:
fmed-11-1329778.pdf
Size:
2.73 MB
Format:
Adobe Portable Document Format
File Type:
text
License:
https://creativecommons.org/licenses/by/4.0
Content:
published

Collections