Hippocampal volume in patients with bilateral and unilateral peripheral vestibular dysfunction.
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BORIS DOI
Date of Publication
September 28, 2022
Publication Type
Article
Contributor
Series
NeuroImage: Clinical
ISSN or ISBN (if monograph)
2213-1582
Publisher
Elsevier
Language
English
Publisher DOI
PubMed ID
36209619
Uncontrolled Keywords
Description
Previous studies have found that peripheral vestibular dysfunction is associated with altered volumes in different brain structures, especially in the hippocampus. However, published evidence is conflicting. Based on previous findings, we compared hippocampal volume, as well as supramarginal, superior temporal, and postcentral gyrus in a sample of 55 patients with different conditions of peripheral vestibular dysfunction (bilateral, chronic unilateral, acute unilateral) to 39 age- and sex-matched healthy controls. In addition, we explored deviations in gray-matter volumes in hippocampal subfields. We also analysed correlations between morphometric data and visuo-spatial performance. Patients with vestibular dysfunction did not differ in total hippocampal volume from healthy controls. However, a reduced volume in the right presubiculum of the hippocampus and the left supramarginal gyrus was observed in patients with chronic and acute unilateral vestibular dysfunction, but not in patients with bilateral vestibular dysfunction. No association of altered volumes with visuo-spatial performance was found. An asymmetric vestibular input due to unilateral vestibular dysfunction might lead to reduced central brain volumes that are involved in vestibular processing.
File(s)
File | File Type | Format | Size | License | Publisher/Copright statement | Content | |
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1-s2.0-S2213158222002777-main.pdf | text | Adobe PDF | 1.22 MB | Attribution (CC BY 4.0) | published |