Lexis and Grammar of Mitochondrial RNA Processing in Trypanosomes

DOI
Publisher DOI
PubMed ID
32191849
Abstract
Trypanosoma brucei spp. cause African human and animal trypanosomiasis, a burden on health and economy in Africa. These hemoflagellates are distinguished by a kinetoplast nucleoid containing mitochondrial DNAs of two kinds: maxicircles encoding ribosomal RNAs (rRNAs) and proteins and minicircles bearing guide RNAs (gRNAs) for mRNA editing. All RNAs are produced by a phage-type RNA polymerase as 3' extended precursors, which undergo exonucleolytic trimming. Most pre-mRNAs proceed through 3' adenylation, uridine insertion/deletion editing, and 3' A/U-tailing. The rRNAs and gRNAs are 3' uridylated. Historically, RNA editing has attracted major research effort, and recently essential pre- and postediting processing events have been discovered. Here, we classify the key players that transform primary transcripts into mature molecules and regulate their function and turnover.
Date Issued
2020-02-28
Publication Type
Article
Subject(s)
Language(s)
en
Author(s)
Aphasizheva, Inna
Alfonzo, Juan
Carnes, Jason
Cestari, Igor
Cruz-Reyes, Jorge
Göringer, H. Ulrich
Hajduk, Stephen
Lukeš, Julius
Madison-Antenucci, Susan
Maslov, Dmitri A.
McDermott, Suzanne M.
Read, Laurie K.
Salavati, Reza
Schnaufer, Achim
Simpson, Larry
Stuart, Kenneth
Yurchenko, Vyacheslav
Zhou, Z. Hong
Zíková, Alena
Zhang, Liye
Zimmer, Sara
Aphasizhev, Ruslan
Additional Credits
Journal
Trends in parasitology
Publisher
Elsevier Current Trends
ISSN
1471-4922
Access(Rights)
restricted
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