Fatality Rates After Infection With the Omicron Variant (B.1.1.529): How Deadly has it been? A Systematic Review and Meta-Analysis.
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BORIS DOI
Publisher DOI
PubMed ID
38855048
Description
BACKGROUND
Since late 2019, the global community has been gripped by the uncertainty surrounding the SARS-CoV-2 pandemic. In November 2021, the emergence of the Omicron variant in South Africa added a new dimension. This study aims to assess the disease's severity and determine the extent to which vaccinations contribute to reducing mortality rates.
METHODS
A systematic review and meta-analysis of the epidemiological implications of the omicron variant of SARS-CoV-2 were performed, incorporating an analysis of articles from November 2021that address mortality rates.
RESULTS
The analysis incorporated data from 3,214,869 patients infected with omicron, as presented in 270 articles. A total of 6,782 deaths from the virus were recorded (0.21%). In the analysed articles, the pooled mortality rate was 0.003 and the pooled in-house mortality rate was 0.036. Vaccination is an effective step in preventing death (odds ratio: 0.391, p < 0.01).
CONCLUSION
The mortality rates for the omicron variant are lower than for the preceding delta variant. mRNA vaccination affords secure and effective protection against severe disease and death from omicron.
Since late 2019, the global community has been gripped by the uncertainty surrounding the SARS-CoV-2 pandemic. In November 2021, the emergence of the Omicron variant in South Africa added a new dimension. This study aims to assess the disease's severity and determine the extent to which vaccinations contribute to reducing mortality rates.
METHODS
A systematic review and meta-analysis of the epidemiological implications of the omicron variant of SARS-CoV-2 were performed, incorporating an analysis of articles from November 2021that address mortality rates.
RESULTS
The analysis incorporated data from 3,214,869 patients infected with omicron, as presented in 270 articles. A total of 6,782 deaths from the virus were recorded (0.21%). In the analysed articles, the pooled mortality rate was 0.003 and the pooled in-house mortality rate was 0.036. Vaccination is an effective step in preventing death (odds ratio: 0.391, p < 0.01).
CONCLUSION
The mortality rates for the omicron variant are lower than for the preceding delta variant. mRNA vaccination affords secure and effective protection against severe disease and death from omicron.
Date of Publication
2024-06-01
Publication Type
Article
Subject(s)
Keyword(s)
B.1.1.529 COVID-19 ICU care Omicron SARS-CoV-2 intensive care
Language(s)
en
Contributor(s)
Ahmad, Suhaib JS | |
Degiannis, Jason R | |
Borucki, Joseph | |
Pouwels, Sjaak | |
Rawaf, David Laith | |
Lala, Anil | |
Whiteley, Graham S | |
Head, Marion | |
Simpson, Angharad | |
Archid, Rami | |
Ahmed, Ahmed R | |
Soler, J Agustin | |
Wichmann, Doerte | |
Thangavelu, Mohanarangam | |
Abdulmajed, Mohamed | |
Elmousili, Mahmoud | |
Lin, Yan-Ren | |
Gelber, Edgar |
Additional Credits
Series
Journal of acute medicine
Publisher
Ainosco Press
ISSN
2211-5587
Access(Rights)
restricted