Publication:
The Identification of Synthetic Impurities in a Vape Pen Containing Δ9-Tetrahydrocannabiphorol Using Gas Chromatography Coupled with Mass Spectrometry

cris.virtualsource.author-orcidd1a341c4-036f-47a6-8596-9e0f65c50176
cris.virtualsource.author-orcidd15fbd74-75d8-4d5c-af34-c5ddef96dc39
cris.virtualsource.author-orcid9c84d5c2-3ee2-4d69-baee-d1b9b70b535f
datacite.rightsopen.access
dc.contributor.authorSchirmer, Willi
dc.contributor.authorSchürch, Stefan
dc.contributor.authorWeinmann, Wolfgang
dc.date.accessioned2024-10-21T12:21:13Z
dc.date.available2024-10-21T12:21:13Z
dc.date.issued2024-10-12
dc.description.abstractΔ9-Tetrahydrocannabiphorol (Δ9-THCP, THCP) a psychoactive cannabinoid recently found in Cannabis sativa L., is widely used as a legal marijuana substitute. THCP is encountered in sprayed Cannabis, edibles, and vape liquids. The distributors of such products claim that the THCP in use originates from a natural source. The legal status of this substance varies from country to country. THCP and similar cannabinoids with a dibenzoyprane structure have been banned in Switzerland since October 2023. A vape liquid, which contains 90% THCP and 10% terpenes according to the distributor, was analyzed by gas chromatography coupled with mass spectrometry (GC-MS). Besides CBP, CBDP, Δ9-THCP and Δ8-THCP and some terpenes, other compounds were found which probably result from a synthetic procedure. This sample contained 5-heptylresorcinol, the heptyl homologue of olivetol, a common precursor for the synthesis of tetrahydrocannabinol (THC). Bisalkylated compounds (m/z 476) were found as a result of the reaction of one equivalent of 5-heptylresorcinol with two equivalents of (+)-p-mentha-1,8-dien-4-ol or another precursor. Similar bisalkylated compounds are known as undesired side products of the synthesis of THC. The sample contained unidentified isomers of Δ9-THCP, presumably abnormal cannabinoids (abn-Δ9-THCP; abn-Δ8-THCP) and iso-cannabinoids (iso-THCP). Chiral derivatization with Mosher acid chlorides revealed that the Δ9-THCP in the sample was enantiopure.
dc.description.sponsorshipInstitute of Forensic Medicine, Forensic Chemistry and Toxicology
dc.description.sponsorshipDCBP Gruppe Prof. Schürch
dc.identifier.doi10.48620/36404
dc.identifier.publisherDOI10.3390/psychoactives3040030
dc.identifier.urihttps://boris-portal.unibe.ch/handle/20.500.12422/125176
dc.language.isoen
dc.publisherMDPI
dc.relation.ispartofPsychoactives
dc.relation.issn2813-1851
dc.titleThe Identification of Synthetic Impurities in a Vape Pen Containing Δ9-Tetrahydrocannabiphorol Using Gas Chromatography Coupled with Mass Spectrometry
dc.typearticle
dspace.entity.typePublication
dspace.file.typetext
oaire.citation.endPage500
oaire.citation.issue4
oaire.citation.startPage491
oaire.citation.volume3
oairecerif.author.affiliationInstitute of Forensic Medicine, Forensic Chemistry and Toxicology
oairecerif.author.affiliationDCBP Gruppe Prof. Schürch
oairecerif.author.affiliationInstitute of Forensic Medicine, Forensic Chemistry and Toxicology
oairecerif.author.affiliation2Institute of Forensic Medicine
unibe.contributor.correspondingSchirmer, Willi
unibe.contributor.roleauthor
unibe.contributor.roleauthor
unibe.contributor.roleauthor
unibe.corresponding.affiliationInstitute of Forensic Medicine, Forensic Chemistry and Toxicology
unibe.description.ispublishedpub
unibe.refereedtrue
unibe.subtype.articlejournal

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