Publication: The Identification of Synthetic Impurities in a Vape Pen Containing Δ9-Tetrahydrocannabiphorol Using Gas Chromatography Coupled with Mass Spectrometry
cris.virtualsource.author-orcid | d1a341c4-036f-47a6-8596-9e0f65c50176 | |
cris.virtualsource.author-orcid | d15fbd74-75d8-4d5c-af34-c5ddef96dc39 | |
cris.virtualsource.author-orcid | 9c84d5c2-3ee2-4d69-baee-d1b9b70b535f | |
datacite.rights | open.access | |
dc.contributor.author | Schirmer, Willi | |
dc.contributor.author | Schürch, Stefan | |
dc.contributor.author | Weinmann, Wolfgang | |
dc.date.accessioned | 2024-10-21T12:21:13Z | |
dc.date.available | 2024-10-21T12:21:13Z | |
dc.date.issued | 2024-10-12 | |
dc.description.abstract | Δ9-Tetrahydrocannabiphorol (Δ9-THCP, THCP) a psychoactive cannabinoid recently found in Cannabis sativa L., is widely used as a legal marijuana substitute. THCP is encountered in sprayed Cannabis, edibles, and vape liquids. The distributors of such products claim that the THCP in use originates from a natural source. The legal status of this substance varies from country to country. THCP and similar cannabinoids with a dibenzoyprane structure have been banned in Switzerland since October 2023. A vape liquid, which contains 90% THCP and 10% terpenes according to the distributor, was analyzed by gas chromatography coupled with mass spectrometry (GC-MS). Besides CBP, CBDP, Δ9-THCP and Δ8-THCP and some terpenes, other compounds were found which probably result from a synthetic procedure. This sample contained 5-heptylresorcinol, the heptyl homologue of olivetol, a common precursor for the synthesis of tetrahydrocannabinol (THC). Bisalkylated compounds (m/z 476) were found as a result of the reaction of one equivalent of 5-heptylresorcinol with two equivalents of (+)-p-mentha-1,8-dien-4-ol or another precursor. Similar bisalkylated compounds are known as undesired side products of the synthesis of THC. The sample contained unidentified isomers of Δ9-THCP, presumably abnormal cannabinoids (abn-Δ9-THCP; abn-Δ8-THCP) and iso-cannabinoids (iso-THCP). Chiral derivatization with Mosher acid chlorides revealed that the Δ9-THCP in the sample was enantiopure. | |
dc.description.sponsorship | Institute of Forensic Medicine, Forensic Chemistry and Toxicology | |
dc.description.sponsorship | DCBP Gruppe Prof. Schürch | |
dc.identifier.doi | 10.48620/36404 | |
dc.identifier.publisherDOI | 10.3390/psychoactives3040030 | |
dc.identifier.uri | https://boris-portal.unibe.ch/handle/20.500.12422/125176 | |
dc.language.iso | en | |
dc.publisher | MDPI | |
dc.relation.ispartof | Psychoactives | |
dc.relation.issn | 2813-1851 | |
dc.title | The Identification of Synthetic Impurities in a Vape Pen Containing Δ9-Tetrahydrocannabiphorol Using Gas Chromatography Coupled with Mass Spectrometry | |
dc.type | article | |
dspace.entity.type | Publication | |
dspace.file.type | text | |
oaire.citation.endPage | 500 | |
oaire.citation.issue | 4 | |
oaire.citation.startPage | 491 | |
oaire.citation.volume | 3 | |
oairecerif.author.affiliation | Institute of Forensic Medicine, Forensic Chemistry and Toxicology | |
oairecerif.author.affiliation | DCBP Gruppe Prof. Schürch | |
oairecerif.author.affiliation | Institute of Forensic Medicine, Forensic Chemistry and Toxicology | |
oairecerif.author.affiliation2 | Institute of Forensic Medicine | |
unibe.contributor.corresponding | Schirmer, Willi | |
unibe.contributor.role | author | |
unibe.contributor.role | author | |
unibe.contributor.role | author | |
unibe.corresponding.affiliation | Institute of Forensic Medicine, Forensic Chemistry and Toxicology | |
unibe.description.ispublished | pub | |
unibe.refereed | true | |
unibe.subtype.article | journal |
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