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Alopecia areata universalis elicited during treatment with adalimumab

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cris.virtualsource.author-orcid5fcd9467-3cf3-49dd-b5d9-2ef9670de6b6
cris.virtualsource.author-orcid657eb181-3137-4b10-9226-937f459da4de
datacite.rightsopen.access
dc.contributor.authorPelivani, Nedzmidin
dc.contributor.authorHassan, Akmal S
dc.contributor.authorBraathen, Lasse R
dc.contributor.authorHunger, Robert
dc.contributor.authorYawalkar, Nikhil
dc.date.accessioned2024-10-13T18:14:03Z
dc.date.available2024-10-13T18:14:03Z
dc.date.issued2008
dc.description.abstractAdalimumab is a fully humanized recombinant anti-tumour-necrosis-factor (TNF-alpha) monoclonal antibody which has been approved for rheumatoid arthritis, active ankylosing spondylitis, psoriatic arthritis and Crohn's disease. We report a case of alopecia areata (AA) universalis occurring 6 months after administration of adalimumab monotherapy in a patient with a long-standing history of psoriatic arthritis and psoriasis. The diagnosis was confirmed by a scalp biopsy which showed a peribulbar infiltrate of both CD4+ and CD8+ T cells, CD1a+ dendritic cells as well as CD68+ and CD163+ macrophages. In addition, immunofluorescence staining for TNF-alpha was found in the mononuclear cell infiltrate. This case suggests a complex role of TNF-alpha in the induction of AA.
dc.description.numberOfPages4
dc.description.sponsorshipUniversitätsklinik für Dermatologie
dc.identifier.doi10.48350/27678
dc.identifier.isi000253912000007
dc.identifier.pmid18230980
dc.identifier.publisherDOI10.1159/000113945
dc.identifier.urihttps://boris-portal.unibe.ch/handle/20.500.12422/101081
dc.language.isoen
dc.publisherKarger
dc.publisher.placeBasel
dc.relation.isbn18230980
dc.relation.ispartofDermatology
dc.relation.issn1018-8665
dc.relation.organizationDCD5A442BAD9E17DE0405C82790C4DE2
dc.titleAlopecia areata universalis elicited during treatment with adalimumab
dc.typearticle
dspace.entity.typePublication
dspace.file.typetext
oaire.citation.endPage3
oaire.citation.issue4
oaire.citation.startPage320
oaire.citation.volume216
oairecerif.author.affiliationUniversitätsklinik für Dermatologie
oairecerif.author.affiliationUniversitätsklinik für Dermatologie
unibe.contributor.rolecreator
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unibe.contributor.rolecreator
unibe.contributor.rolecreator
unibe.contributor.rolecreator
unibe.date.licenseChanged2023-06-21 09:53:09
unibe.description.ispublishedpub
unibe.eprints.legacyId27678
unibe.journal.abbrevTitleDERMATOLOGY
unibe.refereedtrue
unibe.subtype.articlecontribution

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