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  3. The Impact of Pneumococcal Conjugate Vaccine (PCV) Coverage Heterogeneities on the Changing Epidemiology of Invasive Pneumococcal Disease in Switzerland, 2005–2019
 

The Impact of Pneumococcal Conjugate Vaccine (PCV) Coverage Heterogeneities on the Changing Epidemiology of Invasive Pneumococcal Disease in Switzerland, 2005–2019

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BORIS DOI
10.48350/156390
Date of Publication
May 18, 2021
Publication Type
Article
Division/Institute

Institut für Infektio...

Institut für Infektio...

Institut für Infektio...

Author
Oyewole, Oluwaseun Rume-Abiola
Institut für Infektionskrankheiten (IFIK)
Institut für Infektionskrankheiten, Forschung
Lang, Phung
Albrich, Werner C.
Wissel, Kerstin
Leib, Stephenorcid-logo
Institut für Infektionskrankheiten (IFIK)
Casanova, Carloorcid-logo
Institut für Infektionskrankheiten, Allgemeine Bakteriologie
Hilty, Markusorcid-logo
Institut für Infektionskrankheiten, Forschung
Institut für Infektionskrankheiten (IFIK)
Subject(s)

500 - Science::570 - ...

600 - Technology::610...

Series
Microorganisms
ISSN or ISBN (if monograph)
2076-2607
Publisher
MDPI
Language
English
Publisher DOI
10.3390/microorganisms9051078
PubMed ID
34069761
Description
Pneumococcal conjugate vaccines (PCVs) have lowered the incidence of invasive pneumococcal disease (IPD) worldwide. However, the influence of regional vaccine uptake differences on the changing epidemiology of IPD remains unclear. We aimed to examine the overall impact of both seven- and 13-valent PCVs (PCV7 and PCV13) on IPD in Switzerland. Three-year periods from 2005–2010 and 2011–2019 were considered, respectively, as (early and late) PCV7 eras and (early, mid and late) PCV13 eras. Vaccine coverage was estimated from a nationwide survey according to east (German-speaking) and west (French/Italian-speaking) regions for each period. Reported incidence rate ratios (IRRs) were compared between successive periods and regions using nationwide IPD surveillance data. Overall IPD incidence across all ages was only 16% lower in the late PCV13 era compared to the early PCV7 era (IRR 0.83, 95% CI 0.79–0.88), due to increasing incidence of non-PCV-type IPD (2.59, 2.37–2.83) in all age groups, except children <5 years. PCV uptake rates in swiss children were slightly higher in the west than the east (p < 0.001), and were accompanied by lower IPD incidences across all age groups in the former region. Post-PCV13, non-PCV serotypes 8, 22F and 9N were the major cause of IPD in adults ≥65 years. Increased PCV coverage in both areas of Switzerland resulted in a decrease in vaccine-type and overall IPD incidence across all age groups, in a regionally dependent manner. However, the rising incidence of non-vaccine-type IPD, exclusive to older adults, may undermine indirect beneficial effects.
Handle
https://boris-portal.unibe.ch/handle/20.500.12422/56837
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microorganisms-09-01078.pdftextAdobe PDF1.07 MBAttribution (CC BY 4.0)publishedOpen
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