Publication:
Surgical Site Infections, Risk Factors, and Outcomes After Liver Transplant.

cris.virtual.author-orcid0000-0002-7870-912X
cris.virtual.author-orcid0000-0003-4562-9016
cris.virtualsource.author-orcid007a455c-6f7d-4906-a0db-2a2c547fca83
cris.virtualsource.author-orcid5cf54cef-0b9b-48ee-a517-51eafd1fb458
cris.virtualsource.author-orcida4094c89-e546-4ec5-8814-a2e707b77691
datacite.rightsopen.access
dc.contributor.authorSchreiber, Peter W
dc.contributor.authorHoessly, Linard D
dc.contributor.authorBoggian, Katia
dc.contributor.authorNeofytos, Dionysios
dc.contributor.authorvan Delden, Christian
dc.contributor.authorEgli, Adrian
dc.contributor.authorDickenmann, Michael
dc.contributor.authorHirzel, Cédric
dc.contributor.authorManuel, Oriol
dc.contributor.authorKoller, Michael
dc.contributor.authorRossi, Simona
dc.contributor.authorBanz, Vanessa
dc.contributor.authorCompagnon, Philippe
dc.contributor.authorDutkowski, Philipp
dc.contributor.authorKremer, Andreas E
dc.contributor.authorBerzigotti, Annalisa
dc.contributor.authorVionnet, Julien
dc.contributor.authorGoossens, Nicolas
dc.contributor.authorSemela, David
dc.contributor.authorKünzler-Heule, Patrizia
dc.contributor.authorBernsmeier, Christine
dc.contributor.authorKuster, Stefan P
dc.contributor.authorStampf, Susanne
dc.contributor.authorMueller, Nicolas J
dc.date.accessioned2025-04-03T16:12:46Z
dc.date.available2025-04-03T16:12:46Z
dc.date.issued2025-03-03
dc.description.abstractImportance Surgical site infections (SSIs) are one of the most common health care-associated infections. Surgical site infections can have harmful effects in liver transplant (LT) recipients.Objective To assess the incidence of SSI after LT and identify risk factors associated with SSIs and whether SSIs are associated with death and graft loss.Design, Setting, And Participants A multicenter cohort study encompassing data on LT performed at all Swiss transplant centers between May 1, 2008, and September 30, 2020, was conducted. Data analyses were performed in 2023.Exposure Liver transplant.Main Outcomes And Measures Frequency of SSIs within 90 days after transplant, risk factors associated with SSIs, and association of SSIs with 1-year death or graft loss. Surgical site infections were defined according to Centers for Disease Control and Prevention criteria with SSIs occurring within 90 days after LT. For association with posttransplant outcomes, 1-year follow-up data were analyzed.Results Among 1333 LT recipients in the Swiss Transplant Cohort Study, 1158 adults were included in analyses. Median age was 57.2 (IQR, 49.3-62.8) years and 792 were men (68.4%). Seventy patients (6.0%) had an SSI. Most SSIs were deep incisional (9 [12.8%]) or organ-space infections (54 [77.1%]). In most SSIs (56 [80.0%]), bacteria were detected, most frequently Enterococcus spp (36 of 75 [48.0%]) and Escherichia coli (12 of 75 [16.0%]). In multivariable analysis, prior liver transplant (odds ratio [OR] 4.01; 95% CI, 1.44-11.18; P = .008) and living liver donation (OR, 4.08; 95% CI, 1.37-12.16; P = .01) were independent risk factors associated with SSIs. Surgical site infections were independently associated with graft loss and/or death (hazard ratio [HR], 3.24; 95% CI, 1.82-5.79; P < .001); this association was observed in separate analyses on graft loss (HR, 2.97; 95% CI, 1.32-6.68; P = .02) and death (HR, 3.25; 95% CI, 1.44-7.35; P = .01).Conclusions And Relevance The findings of this study suggest that prior liver transplant and living liver donation are independent risk factors associated with SSIs and that SSIs are independently associated with graft loss and/or death, highlighting the relevance of this health care-associated infection.
dc.description.sponsorshipClinic of Infectiology
dc.description.sponsorshipClinic of Visceral Surgery and Medicine, Visceral and Transplant Surgery
dc.description.sponsorshipClinic of Visceral Surgery and Medicine, Hepatology
dc.identifier.doi10.48620/87025
dc.identifier.pmid40116828
dc.identifier.publisherDOI10.1001/jamanetworkopen.2025.1333
dc.identifier.urihttps://boris-portal.unibe.ch/handle/20.500.12422/207663
dc.language.isoen
dc.publisherAmerican Medical Association
dc.relation.ispartofJama Network Open
dc.relation.issn2574-3805
dc.subject.ddc600 - Technology::610 - Medicine & health
dc.titleSurgical Site Infections, Risk Factors, and Outcomes After Liver Transplant.
dc.typearticle
dspace.entity.typePublication
dspace.file.typetext
oaire.citation.issue3
oaire.citation.startPagee251333
oaire.citation.volume8
oairecerif.author.affiliationClinic of Infectiology
oairecerif.author.affiliationClinic of Visceral Surgery and Medicine, Visceral and Transplant Surgery
oairecerif.author.affiliationClinic of Visceral Surgery and Medicine, Hepatology
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unibe.subtype.articlejournal

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