Mitochondrial Defunctionalization Supresses Tim-3-Galectin-9 Secretory Pathway in Human Colorectal Cancer Cells and Thus Can Possibly Affect Tumor Immune Escape
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Publisher DOI
Description
The Tim-3-galectin-9 secretory pathway is known to protect various types of cancer cells against host immune surveillance. We found that pharmacologically induced mitochondrial dysfunction leads to a reduced galectin-9 expression/exocytosis in human colorectal cancer cells and re-distribution of this protein (the effect described for various cellular proteins) into mitochondria.
Date of Publication
2019
Publication Type
Article
Subject(s)
Language(s)
en
Contributor(s)
Sakhnevych, Svetlana S. | |
Yasinska, Inna M. | |
Sumbayev, Vadim V. |
Additional Credits
Series
Frontiers in Pharmacology
Publisher
Frontiers
ISSN
1663-9812
Access(Rights)
open.access