Ventilation/perfusion SPECT or SPECT/CT for lung function imaging in patients with pulmonary emphysema?
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BORIS DOI
Date of Publication
July 2015
Publication Type
Article
Division/Institute
Author
Froeling, Vera | |
Heimann, Uwe | |
Huebner, Ralf-Harto | |
Kroencke, Thomas J | |
Doellinger, Felix | |
Geisel, Dominik | |
Hamm, Bernd | |
Brenner, Winfried | |
Schreiter, Nils F |
Subject(s)
Series
Annals of nuclear medicine
ISSN or ISBN (if monograph)
1864-6433
Publisher
Springer
Language
English
Publisher DOI
PubMed ID
25939639
Description
PURPOSE
To evaluate the utility of attenuation correction (AC) of V/P SPECT images for patients with pulmonary emphysema.
MATERIALS AND METHODS
Twenty-one patients (mean age 67.6 years) with pulmonary emphysema who underwent V/P SPECT/CT were included. AC/non-AC V/P SPECT images were compared visually and semiquantitatively. Visual comparison of AC/non-AC images was based on a 5-point likert scale. Semiquantitative comparison assessed absolute counts per lung (aCpLu) and lung lobe (aCpLo) for AC/non-AC images using software-based analysis; percentage counts (PC = (aCpLo/aCpLu) × 100) were calculated. Correlation between AC/non-AC V/P SPECT images was analyzed using Spearman's rho correlation coefficient; differences were tested for significance with the Wilcoxon rank sum test.
RESULTS
Visual analysis revealed high conformity for AC and non-AC V/P SPECT images. Semiquantitative analysis of PC in AC/non-AC images had an excellent correlation and showed no significant differences in perfusion (ρ = 0.986) or ventilation (ρ = 0.979, p = 0.809) SPECT/CT images.
CONCLUSION
AC of V/P SPECT images for lung lobe-based function imaging in patients with pulmonary emphysema do not improve visual or semiquantitative image analysis.
To evaluate the utility of attenuation correction (AC) of V/P SPECT images for patients with pulmonary emphysema.
MATERIALS AND METHODS
Twenty-one patients (mean age 67.6 years) with pulmonary emphysema who underwent V/P SPECT/CT were included. AC/non-AC V/P SPECT images were compared visually and semiquantitatively. Visual comparison of AC/non-AC images was based on a 5-point likert scale. Semiquantitative comparison assessed absolute counts per lung (aCpLu) and lung lobe (aCpLo) for AC/non-AC images using software-based analysis; percentage counts (PC = (aCpLo/aCpLu) × 100) were calculated. Correlation between AC/non-AC V/P SPECT images was analyzed using Spearman's rho correlation coefficient; differences were tested for significance with the Wilcoxon rank sum test.
RESULTS
Visual analysis revealed high conformity for AC and non-AC V/P SPECT images. Semiquantitative analysis of PC in AC/non-AC images had an excellent correlation and showed no significant differences in perfusion (ρ = 0.986) or ventilation (ρ = 0.979, p = 0.809) SPECT/CT images.
CONCLUSION
AC of V/P SPECT images for lung lobe-based function imaging in patients with pulmonary emphysema do not improve visual or semiquantitative image analysis.
File(s)
| File | File Type | Format | Size | License | Publisher/Copright statement | Content | |
|---|---|---|---|---|---|---|---|
| Froeling2015_Article_VentilationPerfusionSPECTOrSPE.pdf | text | Adobe PDF | 810.79 KB | published |