Loss of 15-Hydroxyprostaglandin Dehydrogenase Increases Prostaglandin E2 in Pancreatic Tumors

Publisher DOI
PubMed ID
19820419
Description
Prostaglandin E2 (PGE2) is a product of cyclooxygenase (COX) and PGE synthase (PGES) and deactivated by 15-hydroxyprostaglandin dehydrogenase (PGDH). Down-regulation of PGDH contributes to PGE2 accumulation in lung and colon cancers but has not been identified in pancreatic cancer.
Date of Publication
2010
Publication Type
Article
Language(s)
en
Contributor(s)
Pham, Hung
Chen, Monica
Li, Aihua
King, Jonathan
Dawson, David W.
Park, Jenny
Reber, Howard A.
Hines, O. Joe
Eibl, Guido
Additional Credits
Universitätsklinik für Viszerale Chirurgie und Medizin, Viszeral- und Transplantationschirurgie
Series
Pancreas
Publisher
Lippincott Williams & Wilkins
ISSN
0885-3177
Access(Rights)
metadata.only
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