Publication:
High-Resolution Optical Coherence Tomography in Healthy Individuals Provides Resolution at the Cellular and Subcellular Levels.

cris.virtual.author-orcid0000-0002-8281-2875
cris.virtual.author-orcid0000-0002-7467-7028
cris.virtual.author-orcid0000-0003-3447-2359
cris.virtualsource.author-orcidc6437558-93e1-4600-9a0a-6e0b4bd81f95
cris.virtualsource.author-orcidd9780237-fc35-4038-a9c3-4c3b15a66215
cris.virtualsource.author-orcid42028fe9-07e0-4f24-a7e1-a0b36e6f9597
cris.virtualsource.author-orcid5f7e90b2-83b5-4cd7-961f-1901aed25617
cris.virtualsource.author-orcid1f5a3365-e23c-4b19-b597-2be1e2b15cdb
cris.virtualsource.author-orcidd8f64f38-2823-4eb4-8780-7ac09c3c6660
cris.virtualsource.author-orcidfed58d8f-d8d1-4474-a2e1-17b917714f0b
datacite.rightsopen.access
dc.contributor.authorReche, Jelena
dc.contributor.authorStocker, Andrea
dc.contributor.authorHenchoz, Virgilia Stéphanie Marie
dc.contributor.authorHabra, Oussama
dc.contributor.authorEscher, Pascal
dc.contributor.authorWolf, Sebastian
dc.contributor.authorZinkernagel, Martin Sebastian
dc.date.accessioned2024-10-25T16:53:52Z
dc.date.available2024-10-25T16:53:52Z
dc.date.issued2023-07-03
dc.description.abstractPURPOSE To assess the clinical resolution capacities of a novel high-resolution optical coherence tomography (High-Res OCT). METHODS Eight healthy volunteers were included in this observational study. Using the SPECTRALIS High-Res OCT device (Heidelberg Engineering, Heidelberg) macular b-scans were taken and compared with b-scans acquired with a SPECTRALIS HRA+OCT device (Heidelberg Engineering, Heidelberg). High-Res OCT scans were also compared with hematoxylin and eosin-stained sections from a human donor retina. RESULTS High-Res OCT allowed identification of several retinal structures at the cellular and subcellular levels, namely, cell nuclei of ganglion cells, displaced amacrine cells, cone photoreceptors and retinal pigment epithelial cells compared with the commercial device. Rod photoreceptor nuclei were partially detectable. Localization of cell type-specific nuclei were confirmed by histological sections of human donor retina. Additionally, all three plexus of the retinal vasculature could be visualized. CONCLUSIONS SPECTRALIS High-Res OCT device provides improved resolution compared with the conventional SPECTRALIS HRA+OCT device and allows to identify structures at the cellular level, similar to histological sections. TRANSLATIONAL RELEVANCE High-Res OCT shows improved visualization of retinal structures in healthy individuals and can be used to assess individual cells within the retina.
dc.description.sponsorshipUniversitätsklinik für Augenheilkunde
dc.identifier.doi10.48350/184669
dc.identifier.pmid37428129
dc.identifier.publisherDOI10.1167/tvst.12.7.12
dc.identifier.urihttps://boris-portal.unibe.ch/handle/20.500.12422/168606
dc.language.isoen
dc.publisherAssociation for Research in Vision and Ophthalmology
dc.relation.ispartofTranslational vision science & technology
dc.relation.issn2164-2591
dc.relation.organizationDCD5A442BB12E17DE0405C82790C4DE2
dc.subject.ddc600 - Technology::610 - Medicine & health
dc.titleHigh-Resolution Optical Coherence Tomography in Healthy Individuals Provides Resolution at the Cellular and Subcellular Levels.
dc.typearticle
dspace.entity.typePublication
dspace.file.typetext
oaire.citation.issue7
oaire.citation.startPage12
oaire.citation.volume12
oairecerif.author.affiliationUniversitätsklinik für Augenheilkunde
oairecerif.author.affiliationUniversitätsklinik für Augenheilkunde
oairecerif.author.affiliationUniversitätsklinik für Augenheilkunde
oairecerif.author.affiliationUniversitätsklinik für Augenheilkunde
oairecerif.author.affiliationUniversitätsklinik für Augenheilkunde
oairecerif.author.affiliationUniversitätsklinik für Augenheilkunde
oairecerif.author.affiliationUniversitätsklinik für Augenheilkunde
unibe.contributor.rolecreator
unibe.contributor.rolecreator
unibe.contributor.rolecreator
unibe.contributor.rolecreator
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unibe.contributor.rolecreator
unibe.contributor.rolecreator
unibe.date.licenseChanged2023-07-12 13:33:14
unibe.description.ispublishedpub
unibe.eprints.legacyId184669
unibe.refereedtrue
unibe.subtype.articlejournal

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