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  3. Impact of blue-collar vs. white-collar occupations on disease burden in psoriatic arthritis patients: A Swiss clinical quality management in rheumatic diseases cohort study.
 

Impact of blue-collar vs. white-collar occupations on disease burden in psoriatic arthritis patients: A Swiss clinical quality management in rheumatic diseases cohort study.

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Description
Open Access Funding provided by University of Zurich.
BORIS DOI
10.48350/199572
Date of Publication
October 2024
Publication Type
Article
Division/Institute

Universitätsklinik fü...

Universitätsklinik fü...

Berner Institut für H...

Author
Colla, Nina
Maul, Julia-Tatjana
Vallejo Yagüe, Enriqueta
Berner Institut für Hausarztmedizin (BIHAM) - Dozierende Pharmazie
Berner Institut für Hausarztmedizin (BIHAM) - Forschung Interprofessionelle Grundversorgung
Berner Institut für Hausarztmedizin (BIHAM)
Burden, Andrea Michelle
Möller, Burkhardorcid-logo
Universitätsklinik für Rheumatologie und Immunologie
Nissen, Michael J
Yawalkar, Nikhil
Universitätsklinik für Dermatologie
Papagiannoulis, Eleftherios
Distler, Oliver
Ciurea, Adrian
Micheroli, Raphael
Subject(s)

600 - Technology::610...

300 - Social sciences...

Series
Clinical Rheumatology
ISSN or ISBN (if monograph)
1434-9949
0770-3198
Publisher
Springer
Language
English
Publisher DOI
10.1007/s10067-024-07077-1
PubMed ID
39110326
Uncontrolled Keywords

Manual vs. sedentary ...

Description
Biomechanical stress may exacerbate inflammation in psoriatic arthritis (PsA). This study aimed to investigate disease activity, work disability, and drug response/retention rates in PsA patients among two different occupation's types: blue-collar workers (BCol) with manual labor versus white-collar workers (WCol) with sedentary occupations. PsA patients registered in the Swiss cohort (SCQM) were classified as BCol or WCol workers and assessed at the initiation of a biologic or targeted synthetic disease-modifying anti-rheumatic drug (b-/tsDMARD). We compared the baseline characteristics at treatment start and the DAS28-CRP for the 1-year remission. Treatment retention was investigated using Kaplan-Meier curves and Cox regression analysis. Multivariable models were adjusted for potential confounders. Of 564 patients, 29% were BCol, and 71% were WCol workers. Baseline disease activity was comparable between both groups. BCol workers were predominantly male (79.8%) and more work disabled at baseline (84.0% vs. 27.9%; p < 0.01). One hundred seventy-four treatment courses (TCs) of 165 PsA patients were included for longitudinal analysis. Occupation did not significantly influence the achievement of DAS28-CRP remission at 1 year. Kaplan-Meier analysis (n = 671) indicated longer retention for BCol workers (mean retention duration: 3.15 years vs. 2.15 years, (p = 0.006). However, adjusted Cox regression analysis did not corroborate these findings. This study indicates that physically demanding occupations correlate with increased rates of work disability among PsA patients, while treatment response seems to be unaffected by the patients' occupation type. Additional research is required to thoroughly comprehend the relationship between physical workload, disease activity, and treatment outcomes. Key Points • This study indicates that physically demanding occupations correlate with increased rates of work disability among PsA patients. • The treatment response among of PsA patients seems unaffected by the patients' occupation type.
Handle
https://boris-portal.unibe.ch/handle/20.500.12422/179633
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