Publication:
Novel Autoantibodies in Idiopathic Small Fiber Neuropathy.

cris.virtualsource.author-orcid5cb8c109-6f76-4d92-b2b4-7d83ce12c939
datacite.rightsopen.access
dc.contributor.authorChan, Amanda C Y
dc.contributor.authorWong, Hiu Yi
dc.contributor.authorChong, Yao Feng
dc.contributor.authorLai, Poh San
dc.contributor.authorTeoh, Hock Luen
dc.contributor.authorNg, Alison Y Y
dc.contributor.authorHung, Jennifer H M
dc.contributor.authorChan, Yee Cheun
dc.contributor.authorNg, Kay W P
dc.contributor.authorVijayan, Joy
dc.contributor.authorOng, Jonathan J Y
dc.contributor.authorChandra, Bharatendu
dc.contributor.authorTan, Chi Hsien
dc.contributor.authorRutt, Nurul H
dc.contributor.authorTan, Ti Myen
dc.contributor.authorIsmail, Nur Hafiza
dc.contributor.authorWilder-Smith, Einar
dc.contributor.authorSchwarz, Herbert
dc.contributor.authorChoi, Hyungwon
dc.contributor.authorSharma, Vijay K
dc.contributor.authorMak, Anselm
dc.date.accessioned2024-10-06T19:07:14Z
dc.date.available2024-10-06T19:07:14Z
dc.date.issued2022-01
dc.description.abstractOBJECTIVE Small fiber neuropathy (SFN) is clinically and etiologically heterogeneous. Although autoimmunity has been postulated to be pathophysiologically important in SFN, few autoantibodies have been described. We aimed to identify autoantibodies associated with idiopathic SFN (iSFN) by a novel high-throughput protein microarray platform that captures autoantibodies expressed in the native conformational state. METHODS Sera from 58 SFN patients and 20 age- and gender-matched healthy controls (HCs) were screened against >1,600 immune-related antigens. Fluorescent unit readout and postassay imaging were performed, followed by composite data normalization and protein fold change (pFC) analysis. Analysis of an independent validation cohort of 33 SFN patients against the same 20 HCs was conducted to identify reproducible proteins in both cohorts. RESULTS Nine autoantibodies were screened with statistical significance and pFC criteria in both cohorts, with at least 50% change in serum levels. Three proteins showed consistently high fold changes in main and validation cohorts: MX1 (FC = 2.99 and 3.07, respectively, p = 0.003, q = 0.076), DBNL (FC = 2.11 and 2.16, respectively, p = 0.009, q < 0.003), and KRT8 (FC = 1.65 and 1.70, respectively, p = 0.043, q < 0.003). Further subgroup analysis into iSFN and SFN by secondary causes (secondary SFN) in the main cohort showed that MX1 is higher in iSFN compared to secondary SFN (FC = 1.61 vs 0.106, p = 0.009). INTERPRETATION Novel autoantibodies MX1, DBNL, and KRT8 are found in iSFN. MX1 may allow diagnostic subtyping of iSFN patients. ANN NEUROL 2021.
dc.description.numberOfPages12
dc.description.sponsorshipUniversitätsklinik für Neurologie
dc.identifier.doi10.48350/162043
dc.identifier.pmid34761434
dc.identifier.publisherDOI10.1002/ana.26268
dc.identifier.urihttps://boris-portal.unibe.ch/handle/20.500.12422/58150
dc.language.isoen
dc.publisherWiley-Blackwell
dc.relation.ispartofAnnals of neurology
dc.relation.issn0364-5134
dc.relation.organizationDCD5A442BAE0E17DE0405C82790C4DE2
dc.subject.ddc600 - Technology::610 - Medicine & health
dc.titleNovel Autoantibodies in Idiopathic Small Fiber Neuropathy.
dc.typearticle
dspace.entity.typePublication
dspace.file.typetext
oaire.citation.endPage77
oaire.citation.issue1
oaire.citation.startPage66
oaire.citation.volume91
oairecerif.author.affiliationUniversitätsklinik für Neurologie
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unibe.date.licenseChanged2021-12-20 10:26:52
unibe.description.ispublishedpub
unibe.eprints.legacyId162043
unibe.journal.abbrevTitleANN NEUROL
unibe.refereedtrue
unibe.subtype.articlejournal

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