Pneumocystis jirovecii pneumonia in paediatric acute lymphoblastic leukaemia: A report from the multi-international clinical trial AIEOP-BFM ALL 2009.
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BORIS DOI
Date of Publication
June 2024
Publication Type
Article
Division/Institute
Author
Barnbrock, Anke | |
Möricke, Anja | |
Barbaric, Draga | |
Jones, Neil | |
Moser, Reinhard | |
Rohde, Marius | |
Salvador, Christina | |
Alten, Julia | |
Elitzur, Sarah | |
Groll, Andreas H | |
Lehrnbecher, Thomas |
Subject(s)
Series
British journal of haematology
ISSN or ISBN (if monograph)
1365-2141
Publisher
Wiley
Language
English
Publisher DOI
PubMed ID
38527954
Uncontrolled Keywords
Description
Pneumocystis jirovecii can cause life-threatening pneumonia (PjP), and patients with haematological malignancies are at high risk of this infection. Prophylactic measures have significantly decreased morbidity and mortality, but there is a paucity of contemporary data on the incidence and clinical course of PjP in well-defined and homogenous patient populations, such as children suffering from acute lymphoblastic leukaemia (ALL). In the multi-international trial AIEOP-BFM ALL2009, PjP was diagnosed in six children (incidence 1/1000) and was associated with insufficient prophylaxis in five of them. Although none of the patients died of PjP, the long-term impact of the infection is unclear.
File(s)
File | File Type | Format | Size | License | Publisher/Copright statement | Content | |
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Br_J_Haematol_-_2024_-_Barnbrock_-_Pneumocystis_jirovecii_pneumonia_in_paediatric_acute_lymphoblastic_leukaemia__A_report.pdf | text | Adobe PDF | 307.57 KB | published |