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Alcohol-related context modulates neural correlates of inhibitory control in alcohol dependent patients: Preliminary data from an fMRI study using an alcohol-related Go/NoGo-task

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cris.virtualsource.author-orcid0bfbd1d3-0cdd-423d-944c-e866c9c2bf5f
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cris.virtualsource.author-orcid5440d9d7-8180-4304-8ae6-5ae4a214d1c8
cris.virtualsource.author-orcid27cb285e-f99b-4209-af34-efc6b5cb3838
cris.virtualsource.author-orcid729f7f39-e915-4df8-baa9-65d3275bc976
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cris.virtualsource.author-orcid323e7cc1-b830-466c-89bc-ef819cadac17
dc.contributor.authorStein, Maria
dc.contributor.authorSteiner, Leonie
dc.contributor.authorFey, Werner Martin
dc.contributor.authorConring, Frauke
dc.contributor.authorRieger, Kathryn
dc.contributor.authorFederspiel, Andrea
dc.contributor.authorMoggi, Franz
dc.date.accessioned2024-09-20T09:25:10Z
dc.date.available2024-09-20T09:25:10Z
dc.date.issued2021-02-01
dc.description.abstractAlcohol use disorder (AUD) is characterized by both impaired inhibitory control and heightened cue reactivity, including enhanced craving and drinking urges in response to alcohol-related stimuli. The interaction between these two mechanisms is thought to be crucial in the maintenance of addiction and relapse. The present study used a newly developed alcohol-related Go/NoGo-task to investigate how exposure to alcohol-related cues affects neural processing of inhibitory control in subjects with AUD. Functional magnetic resonance imaging (fMRI) was recorded during performance of a Go/NoGo task, which incorporated alcohol-related and neutral stimuli as Go and NoGo trials in abstinent AUD patients and healthy controls (HC). AUD patients exhibited increased activation of a fronto-striatal-parietal network during successful response inhibition relative to HC. Within the AUD group, activation for alcohol-related (relative to neutral) inhibition was enhanced in regions including bilateral anterior cingulate cortex (ACC), right medial frontal and precentral gyri, and right putamen. Activation differences in the right ACC increased with subjective craving. These preliminary findings suggest that AUD patients need to recruit enhanced neuronal resources for successful inhibition. In parts of the inhibitory network, this hyperactivation is enhanced when inhibition takes place in an alcohol-related context. Activation in the ACC increased stronger in patients experiencing high craving, possibly because of an enhanced conflict. The task introduced here thus allows to investigate neural processing of alcohol-related inhibition in an AUD sample. The preliminary results suggest that exposure to alcohol-related cues intensifies the demand on an already challenged inhibitory system in recently abstinent patients with AUD.
dc.description.sponsorshipInstitut für Psychologie, Abt. Klinische Psychologie und Psychotherapie
dc.description.sponsorshipZentrum für Translationale Forschung der Universitätsklinik für Psychiatrie und Psychotherapie
dc.identifier.doi10.7892/boris.148754
dc.identifier.pmid33157169
dc.identifier.publisherDOI10.1016/j.bbr.2020.112973
dc.identifier.urihttps://boris-portal.unibe.ch/handle/20.500.12422/45185
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofBehavioural brain research
dc.relation.issn0166-4328
dc.relation.organization33BF865BF1D23C90E053960C5C8246BD
dc.relation.organizationDCD5A442BA84E17DE0405C82790C4DE2
dc.subject.ddc600 - Technology::610 - Medicine & health
dc.titleAlcohol-related context modulates neural correlates of inhibitory control in alcohol dependent patients: Preliminary data from an fMRI study using an alcohol-related Go/NoGo-task
dc.typearticle
dspace.entity.typePublication
oaire.citation.startPage112973
oaire.citation.volume398
oairecerif.author.affiliationInstitut für Psychologie, Abt. Klinische Psychologie und Psychotherapie
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oairecerif.author.affiliationZentrum für Translationale Forschung der Universitätsklinik für Psychiatrie und Psychotherapie
oairecerif.author.affiliationZentrum für Translationale Forschung der Universitätsklinik für Psychiatrie und Psychotherapie
oairecerif.author.affiliationZentrum für Translationale Forschung der Universitätsklinik für Psychiatrie und Psychotherapie
oairecerif.author.affiliationZentrum für Translationale Forschung der Universitätsklinik für Psychiatrie und Psychotherapie
oairecerif.author.affiliationZentrum für Translationale Forschung der Universitätsklinik für Psychiatrie und Psychotherapie
oairecerif.author.affiliation2Zentrum für Translationale Forschung der Universitätsklinik für Psychiatrie und Psychotherapie
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unibe.date.licenseChanged2020-12-03 08:04:20
unibe.description.ispublishedpub
unibe.eprints.legacyId148754
unibe.journal.abbrevTitleBEHAV BRAIN RES
unibe.refereedTRUE
unibe.subtype.articlejournal

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