Publication:
Natural Polymorphisms in Mycobacterium tuberculosis Conferring Resistance to Delamanid in Drug-naïve Patients.

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cris.virtual.author-orcid0000-0001-9345-851X
cris.virtual.author-orcid0000-0003-3309-4835
cris.virtual.author-orcid0000-0001-7462-5132
cris.virtual.author-orcid0000-0002-2890-5384
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cris.virtualsource.author-orcid46e90882-3a33-4708-9c63-a66a84d7094f
cris.virtualsource.author-orcid35b45e5f-8e69-4e44-a5d6-7159366ca436
cris.virtualsource.author-orcida47a659b-5a23-43fa-86e3-f9401108114c
cris.virtualsource.author-orcid0c55f9f9-6715-4c84-a42e-995ea3903d58
datacite.rightsopen.access
dc.contributor.authorReichmuth, Martina Larissa
dc.contributor.authorHömke, Rico
dc.contributor.authorZürcher, Kathrin
dc.contributor.authorSander, Peter
dc.contributor.authorAvihingsanon, Anchalee
dc.contributor.authorCollantes, Jimena
dc.contributor.authorLoiseau, Chloé
dc.contributor.authorBorrell, Sonia
dc.contributor.authorReinhard, Miriam
dc.contributor.authorWilkinson, Robert J
dc.contributor.authorYotebieng, Marcel
dc.contributor.authorFenner, Lukas
dc.contributor.authorBöttger, Erik C
dc.contributor.authorGagneux, Sebastien
dc.contributor.authorEgger, Matthias
dc.contributor.authorKeller, Peter Michael
dc.date.accessioned2024-10-05T11:49:58Z
dc.date.available2024-10-05T11:49:58Z
dc.date.issued2020-10-20
dc.description.abstractMutations in the genes of the F420 signaling pathway, including dnn, fgd1, fbiA, fbiB, fbiC, and fbiD, of Mycobacterium tuberculosis (Mtb) complex can lead to delamanid resistance. We searched for such mutations among 129 Mtb strains from Asia, South-America, and Africa using whole-genome sequencing; 70 (54%) strains had at least one mutation in one of the genes. For ten strains with mutations, we determined the minimum inhibitory concentration (MIC) of delamanid. We found one strain from a delamanid-naïve patient carrying the natural polymorphism Tyr29del (ddn) that was associated with a critical MIC to delamanid.
dc.description.numberOfPages5
dc.description.sponsorshipInstitut für Sozial- und Präventivmedizin (ISPM)
dc.description.sponsorshipInstitut für Infektionskrankheiten, Mykobakteriologie
dc.identifier.doi10.7892/boris.146406
dc.identifier.pmid32868333
dc.identifier.publisherDOI10.1128/AAC.00513-20
dc.identifier.urihttps://boris-portal.unibe.ch/handle/20.500.12422/55317
dc.language.isoen
dc.publisherAmerican Society for Microbiology
dc.relation.ispartofAntimicrobial agents and chemotherapy
dc.relation.issn0066-4804
dc.relation.organizationInstitute for Infectious Diseases, Clinical Microbiology
dc.relation.organizationInstitute for Infectious Diseases, General Bacteriology
dc.relation.organizationInstitute of Social and Preventive Medicine
dc.relation.organizationInstitute for Infectious Diseases, Mycobacteriology
dc.relation.schoolGraduate School for Cellular and Biomedical Sciences (GCB)
dc.subject.ddc600 - Technology::610 - Medicine & health
dc.subject.ddc300 - Social sciences, sociology & anthropology::360 - Social problems & social services
dc.titleNatural Polymorphisms in Mycobacterium tuberculosis Conferring Resistance to Delamanid in Drug-naïve Patients.
dc.typearticle
dspace.entity.typePublication
dspace.file.typetext
oaire.citation.endPage20
oaire.citation.issue11
oaire.citation.startPagee00513
oaire.citation.volume64
oairecerif.author.affiliationInstitut für Sozial- und Präventivmedizin (ISPM)
oairecerif.author.affiliationInstitut für Sozial- und Präventivmedizin (ISPM)
oairecerif.author.affiliationInstitut für Sozial- und Präventivmedizin (ISPM)
oairecerif.author.affiliationInstitut für Sozial- und Präventivmedizin (ISPM)
oairecerif.author.affiliationInstitut für Infektionskrankheiten, Mykobakteriologie
oairecerif.author.affiliation2Institut für Infektionskrankheiten, Allgemeine Bakteriologie
oairecerif.author.affiliation3Institut für Infektionskrankheiten, Klinische Mikrobiologie
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unibe.date.licenseChanged2021-01-04 17:26:12
unibe.description.ispublishedpub
unibe.eprints.legacyId146406
unibe.journal.abbrevTitleANTIMICROB AGENTS CH
unibe.refereedtrue
unibe.subtype.articlejournal

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