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What was I thinking? Eye-tracking experiments underscore the bias that architecture exerts on nuclear grading in prostate cancer

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cris.virtualsource.author-orcid04502b90-b95e-412c-ad50-7faf3266dcb2
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cris.virtualsource.author-orcidcc2c237f-7c51-4a63-9940-93e2297fb6ba
cris.virtualsource.author-orcid7c41815a-e7cb-4ac3-aecc-a0a382d9dae4
cris.virtualsource.author-orcidcbbf3121-585f-493e-ab2d-6f67085e73e3
dc.contributor.authorBombari, Dario
dc.contributor.authorMora, Braulio
dc.contributor.authorSchäfer, Stephan
dc.contributor.authorMast, Fred
dc.contributor.authorLehr, Hans-Anton
dc.date.accessioned2024-10-11T13:15:35Z
dc.date.available2024-10-11T13:15:35Z
dc.date.issued2012
dc.description.abstractWe previously reported that nuclear grade assignment of prostate carcinomas is subject to a cognitive bias induced by the tumor architecture. Here, we asked whether this bias is mediated by the non-conscious selection of nuclei that "match the expectation" induced by the inadvertent glance at the tumor architecture. 20 pathologists were asked to grade nuclei in high power fields of 20 prostate carcinomas displayed on a computer screen. Unknown to the pathologists, each carcinoma was shown twice, once before a background of a low grade, tubule-rich carcinoma and once before the background of a high grade, solid carcinoma. Eye tracking allowed to identify which nuclei the pathologists fixated during the 8 second projection period. For all 20 pathologists, nuclear grade assignment was significantly biased by tumor architecture. Pathologists tended to fixate on bigger, darker, and more irregular nuclei when those were projected before kigh grade, solid carcinomas than before low grade, tubule-rich carcinomas (and vice versa). However, the morphometric differences of the selected nuclei accounted for only 11% of the architecture-induced bias, suggesting that it can only to a small part be explained by the unconscious fixation on nuclei that "match the expectation". In conclusion, selection of « matching nuclei » represents an unconscious effort to vindicate the gravitation of nuclear grades towards the tumor architecture.
dc.description.numberOfPages1
dc.description.sponsorshipInstitut für Psychologie, Kognitive Psychologie, Wahrnehmung und Methodenlehre
dc.description.sponsorshipInstitut für Pathologie
dc.identifier.doi10.7892/boris.12442
dc.identifier.isi000305353400070
dc.identifier.pmid22666438
dc.identifier.publisherDOI10.1371/journal.pone.0038023
dc.identifier.urihttps://boris-portal.unibe.ch/handle/20.500.12422/82537
dc.language.isoen
dc.publisherPublic Library of Science
dc.publisher.placeLawrence, Kans.
dc.relation.ispartofPLoS ONE
dc.relation.issn1932-6203
dc.relation.organizationDCD5A442BF89E17DE0405C82790C4DE2
dc.relation.organizationDCD5A442BF8EE17DE0405C82790C4DE2
dc.subject.ddc500 - Science::570 - Life sciences; biology
dc.subject.ddc600 - Technology::610 - Medicine & health
dc.subject.ddc100 - Philosophy::150 - Psychology
dc.titleWhat was I thinking? Eye-tracking experiments underscore the bias that architecture exerts on nuclear grading in prostate cancer
dc.typearticle
dspace.entity.typePublication
dspace.file.typetext
oaire.citation.issue5
oaire.citation.startPagee38023
oaire.citation.volume7
oairecerif.author.affiliationInstitut für Psychologie, Kognitive Psychologie, Wahrnehmung und Methodenlehre
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oairecerif.author.affiliationInstitut für Pathologie
oairecerif.author.affiliationInstitut für Psychologie, Kognitive Psychologie, Wahrnehmung und Methodenlehre
oairecerif.author.affiliationInstitut für Pathologie
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unibe.description.ispublishedpub
unibe.eprints.legacyId12442
unibe.journal.abbrevTitlePLOS ONE
unibe.refereedTRUE
unibe.subtype.articlejournal

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