In Vitro and In Vivo Treatments of Echinococcus Protoscoleces and Metacestodes with Artemisinin and Artemisinin Derivatives

Publisher DOI
PubMed ID
18625777
Description
In vitro treatment of Echinococcus multilocularis and Echinococcus granulosus larval stages with the antimalarials dihydroartemisinin and artesunate (10 to 40 microM) exhibited promising results, while 6 weeks of in vivo treatment of mice infected with E. multilocularis metacestodes (200 mg/kg of body weight/day) had no effect. However, combination treatments of both drugs with albendazole led to a substantial but statistically not significant reduction in parasite weight compared to results with albendazole alone
Date of Publication
2008
Publication Type
Article
Subject(s)
Language(s)
de
Contributor(s)
Lany, C.
Keiser, J.
Ortega-Mora, L. M.
Additional Credits
Series
Antimicrobial agents and chemotherapy
Publisher
American Society for Microbiology
ISSN
0066-4804
Access(Rights)
metadata.only
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