The impact of sex and gender on aortic events in patients with Marfan syndrome.
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BORIS DOI
Publisher DOI
PubMed ID
35543473
Description
OBJECTIVES
Aim of this study was to explore sex and gender differences regarding aortic events in Marfan patients.
METHODS
We analysed all data from our connective tissue disorder database. Only patients with Marfan syndrome were included. For analysis, patients were divided by sex. Female patients were further divided into 2 subgroups; with vs without children. Aortic events were defined as Stanford type A or type B aortic dissection or any aortic intervention.
RESULTS
A population of 183 Marfan patients was analysed for the purpose of this study. One-hundred-four (57%) were male and 79 (43%) were female patients. Thirty-seven (47%) of the 79 female patients had at least one child. Male patients had a significantly higher probability of experiencing an aortic event (p = 0.015) compared to female patients. However, there was no increased probability for recurrent events in male patients compared to female patients (p = 0.063). Follow-up revealed no sex and gender differences in the occurrence of Stanford type A or B aortic dissection between male and female patients (p = 0.324/p = 0.534). While 11% of women with children suffered from peripartum aortic events, 24% experienced Stanford Type A aortic dissection unrelated to pregnancy.
CONCLUSIONS
Male patients have a higher risk of aortic events than female patients. The majority of women were not aware of their Marfan syndrome diagnosis before conceiving. One out of ten women suffered from peripartum Stanford Type A or B aortic dissection. Twice as many female patients with children suffered from aortic dissection unrelated to childbirth. There were no sex and gender differences affecting mortality in Marfan patients.
Aim of this study was to explore sex and gender differences regarding aortic events in Marfan patients.
METHODS
We analysed all data from our connective tissue disorder database. Only patients with Marfan syndrome were included. For analysis, patients were divided by sex. Female patients were further divided into 2 subgroups; with vs without children. Aortic events were defined as Stanford type A or type B aortic dissection or any aortic intervention.
RESULTS
A population of 183 Marfan patients was analysed for the purpose of this study. One-hundred-four (57%) were male and 79 (43%) were female patients. Thirty-seven (47%) of the 79 female patients had at least one child. Male patients had a significantly higher probability of experiencing an aortic event (p = 0.015) compared to female patients. However, there was no increased probability for recurrent events in male patients compared to female patients (p = 0.063). Follow-up revealed no sex and gender differences in the occurrence of Stanford type A or B aortic dissection between male and female patients (p = 0.324/p = 0.534). While 11% of women with children suffered from peripartum aortic events, 24% experienced Stanford Type A aortic dissection unrelated to pregnancy.
CONCLUSIONS
Male patients have a higher risk of aortic events than female patients. The majority of women were not aware of their Marfan syndrome diagnosis before conceiving. One out of ten women suffered from peripartum Stanford Type A or B aortic dissection. Twice as many female patients with children suffered from aortic dissection unrelated to childbirth. There were no sex and gender differences affecting mortality in Marfan patients.
Date of Publication
2022-10-04
Publication Type
Article
Subject(s)
Keyword(s)
Marfan syndrome aortic aneurysm aortic dissection childbirth sex and gender
Language(s)
en
Contributor(s)
Schober, Patrick |
Series
European journal of cardio-thoracic surgery
Publisher
Oxford University Press
ISSN
1873-734X
Access(Rights)
open.access