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  3. Neurotropic Astroviruses in Animals.
 

Neurotropic Astroviruses in Animals.

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BORIS DOI
10.48350/167474
Date of Publication
June 23, 2021
Publication Type
Article
Division/Institute

Department of Clinica...

Contributor
Wildi, Nicole
Department of Clinical Research and Veterinary Public Health, Neurologische Wissenschaften
Seuberlich, Torstenorcid-logo
Department of Clinical Research and Veterinary Public Health, Neurologische Wissenschaften
Series
Viruses
ISSN or ISBN (if monograph)
1999-4915
Publisher
MDPI
Language
English
Publisher DOI
10.3390/v13071201
PubMed ID
34201545
Uncontrolled Keywords

astrovirus neurologic...

Description
Astrovirus infections are among the main causes of diarrhea in children, but their significance for animal health has remained underestimated and largely unknown. This is changing due to the increasing amount of newly identified neurotropic astroviruses in cases of nonsuppurative encephalitis and neurological disease in humans, pigs, ruminant species and minks. Neurological cases in ruminants and humans usually occur sporadically and as isolated cases. This contrasts with the situation in pigs and minks, in which diseases associated with neurotropic astroviruses are endemic and occur on the herd level. Affected animals show neurological signs such as mild ataxia to tetraplegia, loss of orientation or trembling, and the outcome is often fatal. Non-suppurative inflammation with perivascular cuffing, gliosis and neuronal necrosis are typical histological lesions of astrovirus encephalitis. Since astroviruses primarily target the gastrointestinal tract, it is assumed that they infect the brain through the circulatory system or retrograde following the nerves. The phylogenetic analysis of neurotropic astroviruses has revealed that they are genetically closely related, suggesting the presence of viral determinants for tissue tropism and neuroinvasion. In this review, we summarize the current knowledge on neurotropic astrovirus infections in animals and propose future research activities.
Handle
https://boris-portal.unibe.ch/handle/20.500.12422/68867
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viruses-13-01201.pdftextAdobe PDF1.38 MBAttribution (CC BY 4.0)publishedOpen
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