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Sex differences over time for glycemic control, pump use and insulin dose in patients aged 10-40 years with type 1 diabetes: a diabetes registry study.

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dc.contributor.authorBöttcher, Claudia
dc.contributor.authorTittel, Sascha R
dc.contributor.authorMeissner, Thomas
dc.contributor.authorGohlke, Bettina
dc.contributor.authorStachow, Rainer
dc.contributor.authorDost, Axel
dc.contributor.authorWunderlich, Sybille
dc.contributor.authorLowak, Iris
dc.contributor.authorLanzinger, Stefanie
dc.date.accessioned2024-10-09T15:08:13Z
dc.date.available2024-10-09T15:08:13Z
dc.date.issued2021-12
dc.description.abstractINTRODUCTION To evaluate sex differences in people with type 1 diabetes concerning changes in glycemic control and trends in insulin pump use and insulin dose over two decades in adolescents and one-and-a-half decades in adults. RESEARCH DESIGN AND METHODS People aged 10-20 years (data years 1999-2018) and 21-40 years (data years 2004-2018) with type 1 diabetes were identified in the Diabetes Prospective Follow-up Registry (DPV). All available patients' data sets of the respective period were used for linear regression analyses to investigate trends in HbA1c, pump use, insulin doses and body mass index SD scores (BMI-SDS) in females and males. In addition, stratification by migrant background was made for the adolescent group. RESULTS In the youth group (n=68 662), both boys and girls showed an HbA1c decrease over the period examined. After stratification for migrant background, an HbA1c convergence between boys and girls was seen in those without migrant background as of 2016. Usage of insulin pumps increased continuously from 3% (boys and girls) to 47% (boys) and 54% (girls), respectively. The daily insulin dose in units per kilogram body weight and day increased continuously from 1999 to 2018. An insulin dose leveling between boys and girls occurred. BMI-SDS consistently increased in girls whereas only slight variations were observed in boys.The adult group (n=15 380) showed constant HbA1c sex differences from 2004 to 2018 with lower HbA1c level in females. The use of insulin pump therapy rose from 18% to 35% (males) and 30% to 50% (females). CONCLUSIONS The gap in metabolic control between boys and girls with type 1 diabetes seems to close, but predominantly in adolescents without a migrant background. Improved HbA1c was associated with increased insulin pump use, especially in girls.In adult patients, sex differences in metabolic control and insulin pump use persist: women show constantly lower HbA1c values and higher insulin pump use.
dc.description.numberOfPages12
dc.description.sponsorshipUniversitätsklinik für Kinderheilkunde
dc.identifier.doi10.48350/164001
dc.identifier.pmid34969693
dc.identifier.publisherDOI10.1136/bmjdrc-2021-002494
dc.identifier.urihttps://boris-portal.unibe.ch/handle/20.500.12422/66383
dc.language.isoen
dc.publisherBMJ Publishing Group
dc.relation.ispartofBMJ open diabetes research & care
dc.relation.issn2052-4897
dc.relation.organizationDCD5A442BADAE17DE0405C82790C4DE2
dc.relation.organizationDCD5A442C248E17DE0405C82790C4DE2
dc.subjectadolescent medicine adult insulin sex characteristics
dc.subject.ddc600 - Technology::610 - Medicine & health
dc.titleSex differences over time for glycemic control, pump use and insulin dose in patients aged 10-40 years with type 1 diabetes: a diabetes registry study.
dc.typearticle
dspace.entity.typePublication
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oaire.citation.issue2
oaire.citation.volume9
oairecerif.author.affiliationUniversitätsklinik für Kinderheilkunde
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unibe.date.licenseChanged2022-01-19 11:18:11
unibe.description.ispublishedpub
unibe.eprints.legacyId164001
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unibe.subtype.articlejournal

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