Publication:
A randomised phase III study of bevacizumab and carboplatin-pemetrexed chemotherapy with or without atezolizumab, as first-line treatment for advanced pleural mesothelioma: results of the ETOP 13 18 BEAT-meso trial.

Simple item page
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcid2bff83b1-c54c-4723-a3af-09bf7d7bcb5f
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcidc97badae-1049-49ba-9de4-2d29f0a6c9f6
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcidaae5a766-97a6-43f8-8aa9-1c329c78ee25
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcid2a56e015-6a19-4349-bcb4-6c7c94138e18
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcida7997986-bca3-41d8-90a5-6895a34344b6
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
dc.contributor.authorFelip, E
dc.contributor.authorPopat, S
dc.contributor.authorDafni, U
dc.contributor.authorRibi, K
dc.contributor.authorPope, A
dc.contributor.authorCedres, S
dc.contributor.authorShah, R
dc.contributor.authorde Marinis, F
dc.contributor.authorCove Smith, L
dc.contributor.authorBernabé, R
dc.contributor.authorFrüh, M.
dc.contributor.authorNackaerts, K
dc.contributor.authorGreillier, L
dc.contributor.authorScherz, A.
dc.contributor.authorMassuti, B
dc.contributor.authorNadal, E
dc.contributor.authorVila Martinez, L
dc.contributor.authorTalbot, T
dc.contributor.authorRoschitzki-Voser, H
dc.contributor.authorDimopoulou, G
dc.contributor.authorSchär, S
dc.contributor.authorRuepp, B
dc.contributor.authorSavic, S
dc.contributor.authorPeters, S
dc.contributor.authorStahel, R
dc.date.accessioned2025-01-27T08:44:37Z
dc.date.available2025-01-27T08:44:37Z
dc.date.issued2025-01-13
dc.description.abstractBackground The currently approved frontline treatments for diffuse pleural mesothelioma (DPM) are ipilimumab-nivolumab or platinum-pemetrexed. The addition of bevacizumab to chemotherapy improves overall survival (OS). While single-agent immunotherapy or chemotherapy-immunotherapy combinations are superior to chemotherapy monotherapy, there is a potential for synergistic triple combination of chemotherapy, bevacizumab, and immunotherapy.Patients And Methods BEAT-meso is an international open-label, 1:1 randomised phase III trial, with stratification factors histology and stage aiming to determine the efficacy and safety of adding atezolizumab (1200 mg, Q3W until progression) to bevacizumab (15 mg/kg, Q3W until progression) and standard chemotherapy (4-6 cycles of carboplatin AUC5 with pemetrexed 500 mg/m2, Q3W; ABC versus BC) as first-line treatment for advanced DPM. The primary endpoint is OS in all randomised patients, aiming to a relative benefit of 29% (HR=0.708). Secondary endpoints include progression-free survival (PFS), adverse events (AEs) and symptom-specific and global quality of life (QoL).Results Between 30/04/2019 and 7/03/2022, 400 patients were randomised, 200 per arm. 65% had ECOG performance status 1 and 78% had epithelioid histology. At a median follow-up of 35 months (data cut-off 1/09/2023), the median OS was 20.5 months for ABC versus 18.1 months for BC (HR(95%CI): 0.84(0.66-1.06); p=0.14). Median PFS was significantly longer for ABC than BC (9.2 vs 7.6 months); HR: 0.72(0.59-0.89); p=0.0021). Histology showed significant treatment interaction for both PFS and OS, with OS HR: 0.51(0.32-0.80) for non-epithelioid and 1.01(0.77-1.32) for epithelioid (interaction p=0.012). Grade≥3 treatment-related AEs were reported in 55% of patients in ABC and 47% in BC, QoL was maintained with ABC with no clinically meaningful differences from BC.Conclusions The significant benefit in median PFS for ABC found in this study translated into a numerical but not significant increase in median OS. Thus, the primary endpoint was not met. In the pre-specified analysis by histology, superior OS and PFS were found for ABC in non-epithelioid cases.
dc.description.sponsorshipClinic of Medical Oncology
dc.identifier.doi10.48620/84916
dc.identifier.pmid39814199
dc.identifier.publisherDOI10.1016/j.annonc.2024.12.014
dc.identifier.urihttps://boris-portal.unibe.ch/handle/20.500.12422/203572
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofAnnals of Oncology
dc.relation.issn1569-8041
dc.relation.issn0923-7534
dc.subjectMesothelioma
dc.subjectbevacizumab
dc.subjectchemotherapy
dc.subjectimmunotherapy
dc.subjectpleural
dc.subject.ddc600 - Technology::610 - Medicine & health
dc.titleA randomised phase III study of bevacizumab and carboplatin-pemetrexed chemotherapy with or without atezolizumab, as first-line treatment for advanced pleural mesothelioma: results of the ETOP 13 18 BEAT-meso trial.
dc.typearticle
dspace.entity.typePublication
oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliationClinic of Medical Oncology
oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliationClinic of Medical Oncology
oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation2#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation2#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation2#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation2#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation2#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation2#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation2#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation2#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation2#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation2#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation2#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation2#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation2#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation2#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation2#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation2#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation2#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation2#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation2#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation2#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation2#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation2#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation2#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation2#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation2#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation3#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation3#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation3#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation3#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation3#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation3#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation3#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation3#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation3#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation3#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation3#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation3#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation3#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation3#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation3#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation3#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation3#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation3#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation3#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation3#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation3#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation3#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation3#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation3#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation3#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation4#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation4#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation4#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation4#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation4#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation4#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation4#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation4#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation4#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation4#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation4#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation4#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation4#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation4#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation4#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation4#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation4#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation4#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation4#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation4#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation4#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation4#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation4#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation4#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation4#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.role#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.role#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.role#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.role#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.role#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.role#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.role#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.role#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.role#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.role#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.role#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.role#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.role#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.role#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.role#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.role#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.role#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.role#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.role#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.role#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.role#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.role#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.role#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.role#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.role#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.description.ispublishedinpress
unibe.refereedtrue
unibe.subtype.articlejournal

Files

Original bundle
Now showing 1 - 1 of 1
Name:
1-s2.0-S0923753425000031-main.pdf
Size:
1.79 MB
Format:
Adobe Portable Document Format
File Type:
text
License:
https://creativecommons.org/licenses/by-nc-nd/4.0
Content:
accepted
Download

Collections

Publications