RNA duplexes with biphenyl substituents as base replacements are less stable than DNA duplexes
Publisher DOI
PubMed ID
15834493
Abstract
Introduction of a hydrophobic biphenyl-C-nucleotide pair into a 11-mer RNA duplex is associated with a net penalty in the free energy of duplex formation of 2.0 kcal mol(-1) or 10 degrees C in T(m), relative to DNA. These differential stabilities are of relevance with respect to the transcriptional and translational aspects of hydrophobic base-pairs
Date Issued
2005
Publication Type
Article
Subject(s)
Subjects
base
•
BASE-PAIR
•
biphenyl
•
DNA
•
duplex
•
DUPLEXES
•
RNA
•
stability
Language(s)
en
Author(s)
Brotschi, Christine |
Additional Credits
Journal
Chemical communications
Publisher
Royal Society of Chemistry
ISSN
1359-7345
Access(Rights)
restricted