Publication:
Conservation of the RNA Transport Machineries and Their Coupling to Translation Control across Eukaryotes

cris.virtual.author-orcid0000-0002-0510-746X
cris.virtualsource.author-orcid279aeb37-bca2-4053-9371-2dd2a0314cb1
dc.contributor.authorVazquez-Pianzola, Paula
dc.contributor.authorSuter, Beat
dc.date.accessioned2024-10-11T13:03:19Z
dc.date.available2024-10-11T13:03:19Z
dc.date.issued2012
dc.description.abstractRestriction of proteins to discrete subcellular regions is a common mechanism to establish cellular asymmetries and depends on a coordinated program of mRNA localization and translation control. Many processes from the budding of a yeast to the establishment of metazoan embryonic axes and the migration of human neurons, depend on this type of cell polarization. How factors controlling transport and translation assemble to regulate at the same time the movement and translation of transported mRNAs, and whether these mechanisms are conserved across kingdoms is not yet entirely understood. In this review we will focus on some of the best characterized examples of mRNA transport machineries, the "yeast locasome" as an example of RNA transport and translation control in unicellular eukaryotes, and on the Drosophila Bic-D/Egl/Dyn RNA localization machinery as an example of RNA transport in higher eukaryotes. This focus is motivated by the relatively advanced knowledge about the proteins that connect the localizing mRNAs to the transport motors and the many well studied proteins involved in translational control of specific transcripts that are moved by these machineries. We will also discuss whether the core of these RNA transport machineries and factors regulating mRNA localization and translation are conserved across eukaryotes.
dc.description.sponsorshipInstitut für Zellbiologie (IZB)
dc.identifier.doi10.7892/boris.11235
dc.identifier.isi000304945800001
dc.identifier.pmid22666086
dc.identifier.publisherDOI10.1155/2012/287852
dc.identifier.urihttps://boris-portal.unibe.ch/handle/20.500.12422/81414
dc.language.isoen
dc.publisherHindawi
dc.publisher.placeNew York, N.Y.
dc.relation.ispartofComparative and functional genomics
dc.relation.issn1531-6912
dc.relation.organizationDCD5A442C578E17DE0405C82790C4DE2
dc.titleConservation of the RNA Transport Machineries and Their Coupling to Translation Control across Eukaryotes
dc.typearticle
dspace.entity.typePublication
dspace.file.typetext
oaire.citation.startPage287852
oaire.citation.volume2012
oairecerif.author.affiliationInstitut für Zellbiologie (IZB)
unibe.contributor.rolecreator
unibe.contributor.rolecreator
unibe.description.ispublishedpub
unibe.eprints.legacyId11235
unibe.journal.abbrevTitleCOMP FUNCT GENOM
unibe.refereedTRUE
unibe.subtype.articlecontribution

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