Publication: Absence of MHC-II expression by lymph node stromal cells results in autoimmunity.
cris.virtualsource.author-orcid | b0539473-b1e6-491e-b0d4-07768070e755 | |
cris.virtualsource.author-orcid | 688d95b9-c853-48c7-9f2a-b777fbd25184 | |
dc.contributor.author | Dubrot, Juan | |
dc.contributor.author | Duraes, Fernanda V | |
dc.contributor.author | Harlé, Guillaume | |
dc.contributor.author | Schlaeppi, Anjalie | |
dc.contributor.author | Brighouse, Dale | |
dc.contributor.author | Madelon, Natacha | |
dc.contributor.author | Göpfert, Christine | |
dc.contributor.author | Stokar von Neuforn, Nadine | |
dc.contributor.author | Acha-Orbea, Hans | |
dc.contributor.author | Reith, Walter | |
dc.contributor.author | Gannagé, Monique | |
dc.contributor.author | Hugues, Stephanie | |
dc.date.accessioned | 2025-01-08T20:36:25Z | |
dc.date.available | 2025-01-08T20:36:25Z | |
dc.date.issued | 2018-12-17 | |
dc.description.abstract | How lymph node stromal cells (LNSCs) shape peripheral T-cell responses remains unclear. We have previously demonstrated that murine LNSCs, lymphatic endothelial cells (LECs), blood endothelial cells (BECs), and fibroblastic reticular cells (FRCs) use the IFN-γ-inducible promoter IV (pIV) of the MHC class II (MHCII) transactivator CIITA to express MHCII. Here, we show that aging mice (>1 yr old) in which MHCII is abrogated in LNSCs by the selective deletion of pIV exhibit a significant T-cell dysregulation in LNs, including defective Treg and increased effector CD4 and CD8 T-cell frequencies, resulting in enhanced peripheral organ T-cell infiltration and autoantibody production. The proliferation of LN-Tregs interacting with LECs increases following MHCII up-regulation by LECs upon aging or after exposure to IFN-γ, this effect being abolished in mice in which LECs lack MHCII. Overall, our work underpins the importance of LNSCs, particularly LECs, in supporting Tregs and T-cell tolerance. | |
dc.description.numberOfPages | 12 | |
dc.description.sponsorship | Institut für Tierpathologie (ITPA) | |
dc.identifier.doi | 10.7892/boris.127536 | |
dc.identifier.pmid | 30584641 | |
dc.identifier.publisherDOI | 10.26508/lsa.201800164 | |
dc.identifier.uri | https://boris-portal.unibe.ch/handle/20.500.12422/200473 | |
dc.language.iso | en | |
dc.publisher | EMBO Press | |
dc.relation.ispartof | Life science alliance | |
dc.relation.issn | 2575-1077 | |
dc.relation.organization | DCD5A442C072E17DE0405C82790C4DE2 | |
dc.relation.organization | DCD5A442C208E17DE0405C82790C4DE2 | |
dc.relation.organization | DCD5A442C1CCE17DE0405C82790C4DE2 | |
dc.subject.ddc | 600 - Technology::630 - Agriculture | |
dc.subject.ddc | 500 - Science::570 - Life sciences; biology | |
dc.subject.ddc | 600 - Technology::610 - Medicine & health | |
dc.title | Absence of MHC-II expression by lymph node stromal cells results in autoimmunity. | |
dc.type | article | |
dspace.entity.type | Publication | |
dspace.file.type | text | |
oaire.citation.issue | 6 | |
oaire.citation.startPage | e201800164 | |
oaire.citation.volume | 1 | |
oairecerif.author.affiliation | Institut für Tierpathologie (ITPA) | |
oairecerif.author.affiliation | Institut für Tierpathologie (ITPA) | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.date.licenseChanged | 2019-10-23 01:57:08 | |
unibe.description.ispublished | pub | |
unibe.eprints.legacyId | 127536 | |
unibe.journal.abbrevTitle | LSA | |
unibe.refereed | TRUE | |
unibe.subtype.article | journal |
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