Publication:
Absence of MHC-II expression by lymph node stromal cells results in autoimmunity.

cris.virtualsource.author-orcidb0539473-b1e6-491e-b0d4-07768070e755
cris.virtualsource.author-orcid688d95b9-c853-48c7-9f2a-b777fbd25184
dc.contributor.authorDubrot, Juan
dc.contributor.authorDuraes, Fernanda V
dc.contributor.authorHarlé, Guillaume
dc.contributor.authorSchlaeppi, Anjalie
dc.contributor.authorBrighouse, Dale
dc.contributor.authorMadelon, Natacha
dc.contributor.authorGöpfert, Christine
dc.contributor.authorStokar von Neuforn, Nadine
dc.contributor.authorAcha-Orbea, Hans
dc.contributor.authorReith, Walter
dc.contributor.authorGannagé, Monique
dc.contributor.authorHugues, Stephanie
dc.date.accessioned2025-01-08T20:36:25Z
dc.date.available2025-01-08T20:36:25Z
dc.date.issued2018-12-17
dc.description.abstractHow lymph node stromal cells (LNSCs) shape peripheral T-cell responses remains unclear. We have previously demonstrated that murine LNSCs, lymphatic endothelial cells (LECs), blood endothelial cells (BECs), and fibroblastic reticular cells (FRCs) use the IFN-γ-inducible promoter IV (pIV) of the MHC class II (MHCII) transactivator CIITA to express MHCII. Here, we show that aging mice (>1 yr old) in which MHCII is abrogated in LNSCs by the selective deletion of pIV exhibit a significant T-cell dysregulation in LNs, including defective Treg and increased effector CD4 and CD8 T-cell frequencies, resulting in enhanced peripheral organ T-cell infiltration and autoantibody production. The proliferation of LN-Tregs interacting with LECs increases following MHCII up-regulation by LECs upon aging or after exposure to IFN-γ, this effect being abolished in mice in which LECs lack MHCII. Overall, our work underpins the importance of LNSCs, particularly LECs, in supporting Tregs and T-cell tolerance.
dc.description.numberOfPages12
dc.description.sponsorshipInstitut für Tierpathologie (ITPA)
dc.identifier.doi10.7892/boris.127536
dc.identifier.pmid30584641
dc.identifier.publisherDOI10.26508/lsa.201800164
dc.identifier.urihttps://boris-portal.unibe.ch/handle/20.500.12422/200473
dc.language.isoen
dc.publisherEMBO Press
dc.relation.ispartofLife science alliance
dc.relation.issn2575-1077
dc.relation.organizationDCD5A442C072E17DE0405C82790C4DE2
dc.relation.organizationDCD5A442C208E17DE0405C82790C4DE2
dc.relation.organizationDCD5A442C1CCE17DE0405C82790C4DE2
dc.subject.ddc600 - Technology::630 - Agriculture
dc.subject.ddc500 - Science::570 - Life sciences; biology
dc.subject.ddc600 - Technology::610 - Medicine & health
dc.titleAbsence of MHC-II expression by lymph node stromal cells results in autoimmunity.
dc.typearticle
dspace.entity.typePublication
dspace.file.typetext
oaire.citation.issue6
oaire.citation.startPagee201800164
oaire.citation.volume1
oairecerif.author.affiliationInstitut für Tierpathologie (ITPA)
oairecerif.author.affiliationInstitut für Tierpathologie (ITPA)
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unibe.date.licenseChanged2019-10-23 01:57:08
unibe.description.ispublishedpub
unibe.eprints.legacyId127536
unibe.journal.abbrevTitleLSA
unibe.refereedTRUE
unibe.subtype.articlejournal

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