Effect of Collateral Flow on Catheter-Based Assessment of Cardiac Microvascular Obstruction.

DOI
Publisher DOI
PubMed ID
35639221
Abstract
Cardiac microvascular obstruction (MVO) associated with acute myocardial infarction (heart attack) is characterized by partial or complete elimination of perfusion in the myocardial microcirculation. A new catheter-based method (CoFI, Controlled Flow Infusion) has recently been developed to diagnose MVO in the catheterization laboratory during acute therapy of the heart attack. A porcine MVO model demonstrates that CoFI can accurately identify the increased hydraulic resistance of the affected microvascular bed. A benchtop microcirculation model was developed and tuned to reproduce in vivo MVO characteristics. The tuned benchtop model was then used to systematically study the effect of different levels of collateral flow. These experiments showed that measurements obtained in the catheter-based method were adversely affected such that collateral flow may be misinterpreted as MVO. Based on further analysis of the measured data, concepts to mitigate the adverse effects were formulated which allow discrimination between collateral flow and MVO.
Date Issued
2022-09
Publication Type
Article
Subject(s)
Subjects
Balloon catheter Controlled flow infusion Coronary circulation MVO STEMI
Language(s)
en
Author(s)
Schwartz, Robert S
Cesarovic, Nikola
Additional Credits
Journal
Annals of biomedical engineering
Publisher
Springer
ISSN
0090-6964
Access(Rights)
open.access
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