Meropenem alone and in combination with vancomycin in experimental meningitis caused by a penicillin-resistant pneumococcal strain
Publisher DOI
PubMed ID
10691197
Abstract
In a rabbit model of meningitis caused by a pneumococcus highly resistant to penicillin (MIC, 4 microg/ml), meropenem, a broad-spectrum carbapenem, was bactericidal (-0.48+/-0.14 deltalog10 cfu/ml h) and slightly superior to ceftriaxone (-0.34+/-0.23 deltalog10 cfu/ml x h) and vancomycin (-0.39+/-0.19 deltalog10 cfu/ml x h). Although the combination of vancomycin with ceftriaxone was significantly more active than ceftriaxone alone (-0.55+/-0.19 deltalog10 cfu/ml x h), only an insignificant gain was observed by the addition of vancomycin to meropenem (-0.55+/-0.28 deltalog10 cfu/ml x h).
Date Issued
1999
Publication Type
Article
Language(s)
en
Author(s)
Gerber, CM | |
Cottagnoud, M | |
Neftel, KA | |
Cottagnoud, P |
Additional Credits
Journal
European journal of clinical microbiology & infectious diseases
Publisher
Springer
ISSN
0934-9723
ISBN
10691197
Access(Rights)
open.access