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  3. REM sleep stabilizes hypothalamic representation of feeding behavior.
 

REM sleep stabilizes hypothalamic representation of feeding behavior.

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BORIS DOI
10.7892/boris.147377
Date of Publication
August 11, 2020
Publication Type
Article
Division/Institute

Universitätsklinik fü...

Author
Oesch, Lukas Till
Universitätsklinik für Neurologie
Gazea, Mary
Universitätsklinik für Neurologie
Gent, Thomas Clifford
Universitätsklinik für Neurologie
Bandarabadi, Mojtaba
Universitätsklinik für Neurologie
Gutierrez Herrera, Carolina
Universitätsklinik für Neurologie
Adamantidis, Antoine Roger
Universitätsklinik für Neurologie
Subject(s)

600 - Technology::610...

Series
Proceedings of the National Academy of Sciences of the United States of America - PNAS
ISSN or ISBN (if monograph)
0027-8424
Publisher
National Academy of Sciences NAS
Language
English
Publisher DOI
10.1073/pnas.1921909117
PubMed ID
32732431
Uncontrolled Keywords

REM sleep calcium ima...

Description
During rapid eye movement (REM) sleep, behavioral unresponsiveness contrasts strongly with intense brain-wide neural network dynamics. Yet, the physiological functions of this cellular activation remain unclear. Using in vivo calcium imaging in freely behaving mice, we found that inhibitory neurons in the lateral hypothalamus (LHvgat) show unique activity patterns during feeding that are reactivated during REM, but not non-REM, sleep. REM sleep-specific optogenetic silencing of LHvgat cells induced a reorganization of these activity patterns during subsequent feeding behaviors accompanied by decreased food intake. Our findings provide evidence for a role for REM sleep in the maintenance of cellular representations of feeding behavior.
Handle
https://boris-portal.unibe.ch/handle/20.500.12422/55489
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Oesch, 2020, REM sleep stabilizes hypothalamic representation of feeding behavior.pdftextAdobe PDF6.04 MBpublishedOpen
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