REM sleep stabilizes hypothalamic representation of feeding behavior.
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BORIS DOI
Date of Publication
August 11, 2020
Publication Type
Article
Division/Institute
Author
Subject(s)
Series
Proceedings of the National Academy of Sciences of the United States of America - PNAS
ISSN or ISBN (if monograph)
0027-8424
Publisher
National Academy of Sciences NAS
Language
English
Publisher DOI
PubMed ID
32732431
Uncontrolled Keywords
Description
During rapid eye movement (REM) sleep, behavioral unresponsiveness contrasts strongly with intense brain-wide neural network dynamics. Yet, the physiological functions of this cellular activation remain unclear. Using in vivo calcium imaging in freely behaving mice, we found that inhibitory neurons in the lateral hypothalamus (LHvgat) show unique activity patterns during feeding that are reactivated during REM, but not non-REM, sleep. REM sleep-specific optogenetic silencing of LHvgat cells induced a reorganization of these activity patterns during subsequent feeding behaviors accompanied by decreased food intake. Our findings provide evidence for a role for REM sleep in the maintenance of cellular representations of feeding behavior.
File(s)
File | File Type | Format | Size | License | Publisher/Copright statement | Content | |
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Oesch, 2020, REM sleep stabilizes hypothalamic representation of feeding behavior.pdf | text | Adobe PDF | 6.04 MB | published |