Publication: Outcome and treatment of nocardiosis after solid organ transplantation: new insights from a European study.
cris.virtual.author-orcid | 0000-0002-7870-912X | |
cris.virtualsource.author-orcid | 007a455c-6f7d-4906-a0db-2a2c547fca83 | |
datacite.rights | open.access | |
dc.contributor.author | Lebeaux, David | |
dc.contributor.author | Freund, Romain | |
dc.contributor.author | van Delden, Christian | |
dc.contributor.author | Guillot, Hélène | |
dc.contributor.author | Marbus, Sierk D | |
dc.contributor.author | Matignon, Marie | |
dc.contributor.author | Van Wijngaerden, Eric | |
dc.contributor.author | Douvry, Benoit | |
dc.contributor.author | De Greef, Julien | |
dc.contributor.author | Vuotto, Fanny | |
dc.contributor.author | Tricot, Leïla | |
dc.contributor.author | Fernández-Ruiz, Mario | |
dc.contributor.author | Dantal, Jacques | |
dc.contributor.author | Hirzel, Cédric | |
dc.contributor.author | Jais, Jean-Philippe | |
dc.contributor.author | Rodriguez-Nava, Veronica | |
dc.contributor.author | Jacobs, Frédérique | |
dc.contributor.author | Lortholary, Olivier | |
dc.contributor.author | Coussement, Julien | |
dc.date.accessioned | 2024-10-25T05:35:17Z | |
dc.date.available | 2024-10-25T05:35:17Z | |
dc.date.issued | 2017-05-15 | |
dc.description.abstract | Background Solid organ transplant (SOT) recipients are at risk of nocardiosis, a rare opportunistic bacterial infection, but prognosis and outcome of these patients are poorly defined. Our objectives were to identify factors associated with one-year mortality after nocardiosis and describe the outcome of patients receiving short-course antibiotics (≤120 days). Methods We analyzed data from a multicenter European case-control study that included 117 SOT recipients with nocardiosis diagnosed between 2000 and 2014. Factors associated with one-year all-cause mortality were identified using multivariable conditional logistic regression. Results One-year mortality was 10-fold higher in patients with nocardiosis (16.2%, 19/117) than in control transplant recipients (1.3%, 3/233, p<0.001). A history of tumor (odds ratio [OR] 1.4; 95% confidence interval [CI] 1.1-1.8), invasive fungal infection in the six months before nocardiosis (OR 1.3; 95%CI 1.1-1.5) and donor age (OR 1.0046; 95%CI 1.0007-1.0083) were independently associated with one-year mortality. Acute rejection in the year before nocardiosis was associated with improved survival (OR 0.85; 95%CI 0.73-0.98). Seventeen patients received short-course antibiotics (median duration 56 [24-120] days) with a one-year success rate (cured and surviving) of 88% and a 5.9% risk of relapse (median follow-up 49 [6-136] month). Conclusions One-year mortality was 10-fold higher in SOT patients with nocardiosis than in those without. Four factors, largely reflecting general medical condition rather than severity and/or management of nocardiosis, were independently associated with one-year mortality. Patients receiving short-course antibiotic treatment had good outcomes, suggesting this may be a strategy for further study. | |
dc.description.numberOfPages | 10 | |
dc.description.sponsorship | Universitätsklinik für Infektiologie | |
dc.identifier.doi | 10.7892/boris.98331 | |
dc.identifier.pmid | 28329348 | |
dc.identifier.publisherDOI | 10.1093/cid/cix124 | |
dc.identifier.uri | https://boris-portal.unibe.ch/handle/20.500.12422/151644 | |
dc.language.iso | en | |
dc.publisher | Oxford University Press | |
dc.relation.ispartof | Clinical infectious diseases | |
dc.relation.issn | 1058-4838 | |
dc.relation.organization | DCD5A442BB13E17DE0405C82790C4DE2 | |
dc.subject | Nocardia | |
dc.subject | mortality | |
dc.subject | opportunistic infections. | |
dc.subject | organ transplantation | |
dc.subject | prognosis | |
dc.subject.ddc | 600 - Technology::610 - Medicine & health | |
dc.title | Outcome and treatment of nocardiosis after solid organ transplantation: new insights from a European study. | |
dc.type | article | |
dspace.entity.type | Publication | |
dspace.file.type | text | |
oaire.citation.endPage | 1405 | |
oaire.citation.issue | 10 | |
oaire.citation.startPage | 1396 | |
oaire.citation.volume | 64 | |
oairecerif.author.affiliation | Universitätsklinik für Infektiologie | |
unibe.contributor.role | creator | |
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unibe.contributor.role | creator | |
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unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
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unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.date.embargoChanged | 2018-05-16 00:30:08 | |
unibe.description.ispublished | pub | |
unibe.eprints.legacyId | 98331 | |
unibe.journal.abbrevTitle | CLIN INFECT DIS | |
unibe.refereed | true | |
unibe.subtype.article | journal |
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