Statistical inference for the difference between two maximized Youden indices obtained from correlated biomarkers.
Publisher DOI
PubMed ID
33852754
Abstract
Currently, there is global interest in deriving new promising cancer biomarkers that could complement or substitute the conventional ones. Clinical decisions can often be based on the cutoff that corresponds to the maximized Youden index when maximum accuracy drives decisions. When more than one classification criteria are measured within the same individuals, correlated measurements arise. In this work, we propose hypothesis tests and confidence intervals for the comparison of two correlated receiver operating characteristic (ROC) curves in terms of their corresponding maximized Youden indices. We explore delta-based techniques under parametric assumptions, or power transformations. Nonparametric kernel-based methods are also examined. We evaluate our approaches through simulations and illustrate them using data from a metabolomic study referring to the detection of pancreatic cancer.
Date Issued
2021-08
Publication Type
Article
Subject(s)
Subjects
Box-Cox transformation Youden index receiver operating characteristic curve sensitivity specificity
Language(s)
en
Author(s)
Bantis, Leonidas E. | |
Reiser, Benjamin |
Additional Credits
Journal
Biometrical journal
Publisher
Wiley-VCH
ISSN
0323-3847
Access(Rights)
restricted