Progress in Monitoring alcohol consumption and alcohhol abuse by phosphatidylethanol
Publisher DOI
Abstract
For early diagnosis and therapy of alcohol-related disorders,
alcohol biomarkers are highly valuable. Concerning specificity,
indirect markers can be influenced by nonethanol-related factors,
whereas direct markers are only formed after ethanol
consumption. Sensitivity of the direct markers depends on cutoffs
of analytical methods, material for analysis and plays an
important role for their utilization in different fields of application.
Until recently, the biomarker phosphatidylethanol has been used
to differentiate between social drinking and alcohol abuse. After
method optimization, the detection limit could be lowered and
phosphatidylethanol became sensitive enough to even detect the
consumption of low amounts of alcohol. This perspective gives a
summary of most common alcohol biomarkers and summarizes
new developments for monitoring alcohol consumption habits.
alcohol biomarkers are highly valuable. Concerning specificity,
indirect markers can be influenced by nonethanol-related factors,
whereas direct markers are only formed after ethanol
consumption. Sensitivity of the direct markers depends on cutoffs
of analytical methods, material for analysis and plays an
important role for their utilization in different fields of application.
Until recently, the biomarker phosphatidylethanol has been used
to differentiate between social drinking and alcohol abuse. After
method optimization, the detection limit could be lowered and
phosphatidylethanol became sensitive enough to even detect the
consumption of low amounts of alcohol. This perspective gives a
summary of most common alcohol biomarkers and summarizes
new developments for monitoring alcohol consumption habits.
Date Issued
2014
Publication Type
Article
Subject(s)
Language(s)
en
Author(s)
Thierauf, Annette | |
Wurst, Friedrich Martin | |
Thon, Natasha |
Additional Credits
Journal
Bioanalysis
Publisher
Future Science
ISSN
1757-6180
Access(Rights)
restricted