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Adverse pregnancy and neonatal outcomes associated with Neisseria gonorrhoeae, Mycoplasma genitalium, M. hominis, Ureaplasma urealyticum and U. parvum: a systematic review and meta-analysis protocol.

cris.virtual.author-orcid0000-0003-4817-8986
cris.virtualsource.author-orcid343a1442-f67d-4866-bff9-38a594b6d245
cris.virtualsource.author-orcidbb5e3f47-d3b5-4015-aac8-1c096b001132
datacite.rightsopen.access
dc.contributor.authorVallely, Lisa M
dc.contributor.authorEgli, Dianne
dc.contributor.authorPomat, William
dc.contributor.authorHomer, Caroline Se
dc.contributor.authorGuy, Rebecca
dc.contributor.authorWand, Handan
dc.contributor.authorSilver, Bronwyn
dc.contributor.authorRumbold, Alice R
dc.contributor.authorKaldor, John M
dc.contributor.authorLow, Nicola
dc.contributor.authorVallely, Andrew J
dc.date.accessioned2024-10-07T16:47:44Z
dc.date.available2024-10-07T16:47:44Z
dc.date.issued2018-11-28
dc.description.abstractINTRODUCTION Several bacterial sexually transmitted and genital mycoplasma infections during pregnancy have been associated with poor pregnancy and perinatal outcomes. Comprehensive and systematic information about associations between sexually transmitted infections (STI) and genital infections in pregnancy and adverse perinatal outcomes is needed to improve understanding about the evidence for causal associations between these infections and adverse pregnancy and neonatal outcomes. Our primary objective is to systematically review the literature about associations between: (1) in pregnancy and preterm birth; (2) in pregnancy and preterm birth; (3) and/or in pregnancy and preterm birth. METHODS AND ANALYSIS We will undertake a systematic search of Medline, Excerpta Medica database and the Cochrane Library and Cumulative Index to Nursing and Allied Health Literature. Following an initial screening of titles by one reviewer, abstracts will be independently assessed by two reviewers before screening of full-text articles. To exclude a manuscript, both reviewers need to agree on the decision. Any discrepancies will be resolved by discussion, or the adjudication of a third reviewer. Studies will be included if they report testing for one or more of during pregnancy and report pregnancy and/or birth outcomes. In this review, the primary outcome is preterm birth. Secondary outcomes are premature rupture of membranes, low birth weight, spontaneous abortion, stillbirth, neonatal mortality and ophthalmia neonatorum. We will use standard definitions, or definitions reported by study authors. We will examine associations between exposure and outcome in forest plots, using the I statistic to examine between study heterogeneity. Where appropriate, we will use meta-analysis to combine results of individual studies. ETHICS AND DISSEMINATION This systematic review of published literature does not require ethical committee approval. Results of this review will be published in a peer reviewed, open access journal. PROSPERO REGISTRATION NUMBER CRD42016050962.
dc.description.numberOfPages7
dc.description.sponsorshipInstitut für Sozial- und Präventivmedizin (ISPM)
dc.identifier.doi10.7892/boris.122516
dc.identifier.pmid30498048
dc.identifier.publisherDOI10.1136/bmjopen-2018-024175
dc.identifier.urihttps://boris-portal.unibe.ch/handle/20.500.12422/61531
dc.language.isoen
dc.publisherBMJ Publishing Group
dc.relation.ispartofBMJ open
dc.relation.issn2044-6055
dc.relation.organizationDCD5A442BECFE17DE0405C82790C4DE2
dc.subjectadverse pregnancy outcome genital mycoplasmas meta analysis preterm birth sexually transmitted infections systematic review
dc.subject.ddc600 - Technology::610 - Medicine & health
dc.subject.ddc300 - Social sciences, sociology & anthropology::360 - Social problems & social services
dc.titleAdverse pregnancy and neonatal outcomes associated with Neisseria gonorrhoeae, Mycoplasma genitalium, M. hominis, Ureaplasma urealyticum and U. parvum: a systematic review and meta-analysis protocol.
dc.typearticle
dspace.entity.typePublication
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oaire.citation.issue11
oaire.citation.startPagee024175
oaire.citation.volume8
oairecerif.author.affiliationInstitut für Sozial- und Präventivmedizin (ISPM)
oairecerif.author.affiliationInstitut für Sozial- und Präventivmedizin (ISPM)
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unibe.date.licenseChanged2019-10-23 04:22:53
unibe.description.ispublishedpub
unibe.eprints.legacyId122516
unibe.journal.abbrevTitleBMJ Open
unibe.refereedtrue
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