Ein biologisches Lungenmodell mit Forschungspotenzial

Abstract

Standard in vitro models fail to reproduce the complex cellular microenvironment of the human lung, whereas lung animal models poorly predict drug response in humans. A powerful alternative to model various aspects of the air-blood barrier is lung-on-chips using a thin and porous polymeric membrane. Researchers from the University of Bern have developed a new generation lung-on-chip that mimics an array of alveoli based on a biological membrane, on which patient cells are cultured, opening new potentials for lung research, drug screening and personalized medicine.