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  3. Analysis of Polycerate Mutants Reveals the Evolutionary Co-option of HOXD1 for Horn Patterning in Bovidae.
 

Analysis of Polycerate Mutants Reveals the Evolutionary Co-option of HOXD1 for Horn Patterning in Bovidae.

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BORIS DOI
10.48350/151913
Date of Publication
May 19, 2021
Publication Type
Article
Division/Institute

Institut für Genetik

Author
Allais-Bonnet, Aurélie
Hintermann, Aurélie
Deloche, Marie-Christine
Cornette, Raphaël
Bardou, Philippe
Naval-Sanchez, Marina
Pinton, Alain
Haruda, Ashleigh
Grohs, Cécile
Zakany, Jozsef
Bigi, Daniele
Medugorac, Ivica
Putelat, Olivier
Greyvenstein, Ockert
Hadfield, Tracy
Jemaa, Slim Ben
Bunevski, Gjoko
Menzi, Fiona
Institut für Genetik
Hirter, Nathalie
Institut für Genetik
Paris, Julia Maria
Institut für Genetik
Hedges, John
Palhiere, Isabelle
Rupp, Rachel
Lenstra, Johannes A
Gidney, Louisa
Lesur, Joséphine
Schafberg, Renate
Stache, Michael
Wandhammer, Marie-Dominique
Arbogast, Rose-Marie
Guintard, Claude
Blin, Amandine
Boukadiri, Abdelhak
Rivière, Julie
Esquerré, Diane
Donnadieu, Cécile
Danchin-Burge, Coralie
Reich, Coralie M
Riley, David G
van Marle-Koster, Este
Cockett, Noelle
Hayes, Benjamin J
Drögemüller, Cordorcid-logo
Institut für Genetik
Kijas, James
Pailhoux, Eric
Tosser-Klopp, Gwenola
Duboule, Denis
Capitan, Aurélien
Subject(s)

500 - Science::570 - ...

500 - Science::590 - ...

600 - Technology::610...

600 - Technology::630...

Series
Molecular Biology and Evolution
ISSN or ISBN (if monograph)
0737-4038
Publisher
Oxford University Press
Language
English
Publisher DOI
10.1093/molbev/msab021
PubMed ID
33528505
Uncontrolled Keywords

Hox genes co-option g...

Description
In the course of evolution, pecorans (i.e. higher ruminants) developed a remarkable diversity of osseous cranial appendages, collectively referred to as 'headgear', which likely share the same origin and genetic basis. However, the nature and function of the genetic determinants underlying their number and position remain elusive. Jacob and other rare populations of sheep and goats are characterized by polyceraty, the presence of more than two horns. Here, we characterize distinct POLYCERATE alleles in each species, both associated with defective HOXD1 function. We show that haploinsufficiency at this locus results in the splitting of horn bud primordia, likely following the abnormal extension of an initial morphogenetic field. These results highlight the key role played by this gene in headgear patterning and illustrate the evolutionary co-option of a gene involved in the early development of bilateria to properly fix the position and number of these distinctive organs of Bovidae.
Handle
https://boris-portal.unibe.ch/handle/20.500.12422/56119
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File(s)
FileFile TypeFormatSizeLicensePublisher/Copright statementContent
msab021.pdftextAdobe PDF2.24 MBacceptedOpen
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