Life style habits such as alcohol consumption and physical activity in relation to serum apoB / apoA-I ratio amongst 64-year-old women with varying degrees of glucose tolerance.
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BORIS DOI
Publisher DOI
PubMed ID
17908159
Description
OBJECTIVES
To investigate how life style factors such as alcohol consumption and physical activity relate to the serum apoB / apoA-I ratio in a cohort of middle-aged women with varying degrees of glucose tolerance.
DESIGN
Observational, cross-sectional cohort study.
SETTING
Research laboratory at a University Hospital.
SUBJECTS
A screened cohort of 64-year-old postmenopausal women with varying degrees of glucose tolerance, ranging from diabetes (n = 232), impaired (n = 212) and normal (n = 191) glucose tolerance.
MAIN OUTCOME MEASURE
ApoB / apoA-I ratio in relation to alcohol consumption and physical activity as assessed by questionnaires.
RESULTS
Alcohol consumption and regular physical activity at high levels were inversely associated with the serum apoB / apoA-I ratio independently of confounding factors such as obesity, lipid-lowering treatment, degree of glucose tolerance and hormone replacement therapy. Alcohol seemed related to the apoB / apoA-I ratio mainly through increasing apoA-I, whereas physical activity seemed mainly related to lowering of apoB. Alcohol consumption above a daily intake of 8.9 g, i.e. less than a glass of wine was accompanied by a decrease in apoB / apoA-I ratio.
CONCLUSIONS
Amongst these 64-year-old women with varying degrees of glucose tolerance, a moderate alcohol intake and regular physical exercise leading to sweating were associated with lower apoB / apoA-I ratio and these effects seem to be additive.
To investigate how life style factors such as alcohol consumption and physical activity relate to the serum apoB / apoA-I ratio in a cohort of middle-aged women with varying degrees of glucose tolerance.
DESIGN
Observational, cross-sectional cohort study.
SETTING
Research laboratory at a University Hospital.
SUBJECTS
A screened cohort of 64-year-old postmenopausal women with varying degrees of glucose tolerance, ranging from diabetes (n = 232), impaired (n = 212) and normal (n = 191) glucose tolerance.
MAIN OUTCOME MEASURE
ApoB / apoA-I ratio in relation to alcohol consumption and physical activity as assessed by questionnaires.
RESULTS
Alcohol consumption and regular physical activity at high levels were inversely associated with the serum apoB / apoA-I ratio independently of confounding factors such as obesity, lipid-lowering treatment, degree of glucose tolerance and hormone replacement therapy. Alcohol seemed related to the apoB / apoA-I ratio mainly through increasing apoA-I, whereas physical activity seemed mainly related to lowering of apoB. Alcohol consumption above a daily intake of 8.9 g, i.e. less than a glass of wine was accompanied by a decrease in apoB / apoA-I ratio.
CONCLUSIONS
Amongst these 64-year-old women with varying degrees of glucose tolerance, a moderate alcohol intake and regular physical exercise leading to sweating were associated with lower apoB / apoA-I ratio and these effects seem to be additive.
Date of Publication
2007-11
Publication Type
Article
Subject(s)
Language(s)
en
Contributor(s)
Simonsson, M | |
Schmidt, C | |
Helenius, M-L | |
Fagerberg, B |
Additional Credits
Series
Journal of internal medicine
Publisher
Blackwell Scientific Publications
ISSN
0954-6820
Access(Rights)
restricted