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  3. Oxygen regulates molecular mechanisms of cancer progression and metastasis
 

Oxygen regulates molecular mechanisms of cancer progression and metastasis

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BORIS DOI
10.7892/boris.45343
Date of Publication
March 2014
Publication Type
Article
Division/Institute

Institut für Zellbiol...

Author
Gupta, Kartik
Madan, Esha
Sayyid, Muzzammil
Arias-Pulido, Hugo
Moreno, Eduardo
Institut für Zellbiologie (IZB)
Kuppusamy, Periannan
Gogna, Rajan
Institut für Zellbiologie (IZB)
Subject(s)

500 - Science::570 - ...

Series
Cancer and Metastasis Reviews
ISSN or ISBN (if monograph)
1573-7233
Publisher
Springer
Language
English
Publisher DOI
10.1007/s10555-013-9464-2
Description
Oxygen is the basic molecule which supports life and it truly is “god's gift to life.” Despite its immense importance, research on “oxygen biology” has never received the light of the day and has been limited to physiological and biochemical studies. It seems that in modern day biology, oxygen research is summarized in one word “hypoxia.” Scientists have focused on hypoxia-induced transcriptomics and molecular–cellular alterations exclusively in disease models. Interestingly, the potential of oxygen to control the basic principles of biology like homeostatic maintenance, transcription, replication, and protein folding among many others, at the molecular level, has been completely ignored. Here, we present a perspective on the crucial role played by oxygen in regulation of basic biological phenomena. Our conclusion highlights the importance of establishing novel research areas like oxygen biology, as there is great potential in this field for basic science discoveries and clinical benefits to the society.
Handle
https://boris-portal.unibe.ch/handle/20.500.12422/117254
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moreno_madan.pdftextAdobe PDF2.21 MBpublisherpublishedOpen
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