Clinical Impact of Single Nucleotide Polymorphism in CD-19 on Treatment Outcome in FMC63-CAR-T Cell Therapy.
Publisher DOI
PubMed ID
37297020
Abstract
Chimeric antigen receptor (CAR)-T cell therapy is effective in patients with relapsed or refractory diffuse large B-cell lymphoma (r/r DLBCL) with response rates of 63-84% and complete response observed in 43-54%. Common germline variants of the target antigen CD19 may elicit different responses to CAR-T cell therapy. The CD19 gene single nucleotide polymorphism rs2904880 encoding leucine or valine at amino acid position 174 of the CD19 antigen was prevalent in 51% of the studied DLBCL patients. In a retrospective comparative analysis of clinical outcome, there were significant differences in CD19 L174 versus V174 carriers: the median time of progression-free survival was 22 vs. 6 months (p = 0.06), overall survival was 37 vs. 8 months (p = 0.11), complete response rates were 51% vs. 30% (p = 0.05), and refractory disease rates were 14% vs. 32% (p = 0.04). The single nucleotide polymorphism in CD19 was shown to influence the treatment outcome in FMC63-anti-CD19-CAR-T cell therapy, and the CD19 minor allele L174 predicted a favorable treatment outcome.
Date Issued
2023-06-05
Publication Type
Article
Subject(s)
Subjects
Axicaptagene ciloleucel (Yescarta©) B-lymphocyte antigen CD19 CAR-T cell therapy FMC63-chimeric antigen receptor (FMC63-CAR) Lisocabtagene maraleucel (Breyanzi©) Tisagenlecleucel (Kymriah©) minor allele frequency (MAF) single nucleotide polymorphism (SNP)
Language(s)
en
Author(s)
Abbühl, Mariesol |
Additional Credits
Journal
Cancers
Publisher
MDPI AG
ISSN
2072-6694
Access(Rights)
open.access