Association between maternal asthma and impaired infant lung function is diminished by inhaled corticosteroid use in pregnancy.
Publisher DOI
PubMed ID
41207792
Abstract
Background
Infants of asthmatic mothers have reduced lung function in early life for reasons that remain to be defined. The association between inhaled corticosteroid (ICS) use during pregnancy and lung function in the offspring has not been investigated.Objectives
To investigate the association between ICS use during pregnancy and infant lung function.Methods
Multivariable regression analysis of infant lung function at 4-6 weeks (tidal breathing flow volume loops and functional residual capacity (FRC)) associated with use of ICS during pregnancy.Results
Among infants born to asthmatic mothers, the ratio of time to peak tidal expiratory flow to expiratory time (tPTEF:tE), corrected for end-expiratory lung volume (FRC), was improved in offsprings whose mothers used ICS during pregnancy compared with those who did not (n=161 ICS use vs n=25 no ICS use; coefficient 0.06 /mL, 95% CI 0.01 to 0.11, p=0.014). Compared with a control group of infants born to non-asthmatic mothers, there was a lower tPTEF:tE to FRC ratio in infants born to asthmatic mothers without ICS use (n=46 no asthma vs n=25 asthma no ICS use; coefficient -0.08 /mL, 95% CI -0.01 to -0.02, p=0.012) but not in infants born to asthmatic mothers with ICS use (n=46 no asthma vs n=161 asthma ICS use; coefficient -0.02 /mL, 95% CI -0.06 to 0.03, p=0.453).Conclusions
The association between maternal asthma and impaired infant lung function diminished in infants whose mothers used ICS during pregnancy.Trial Registration
Australian New Zealand Clinical Trials Registry ACTRN12613000202763.
Infants of asthmatic mothers have reduced lung function in early life for reasons that remain to be defined. The association between inhaled corticosteroid (ICS) use during pregnancy and lung function in the offspring has not been investigated.Objectives
To investigate the association between ICS use during pregnancy and infant lung function.Methods
Multivariable regression analysis of infant lung function at 4-6 weeks (tidal breathing flow volume loops and functional residual capacity (FRC)) associated with use of ICS during pregnancy.Results
Among infants born to asthmatic mothers, the ratio of time to peak tidal expiratory flow to expiratory time (tPTEF:tE), corrected for end-expiratory lung volume (FRC), was improved in offsprings whose mothers used ICS during pregnancy compared with those who did not (n=161 ICS use vs n=25 no ICS use; coefficient 0.06 /mL, 95% CI 0.01 to 0.11, p=0.014). Compared with a control group of infants born to non-asthmatic mothers, there was a lower tPTEF:tE to FRC ratio in infants born to asthmatic mothers without ICS use (n=46 no asthma vs n=25 asthma no ICS use; coefficient -0.08 /mL, 95% CI -0.01 to -0.02, p=0.012) but not in infants born to asthmatic mothers with ICS use (n=46 no asthma vs n=161 asthma ICS use; coefficient -0.02 /mL, 95% CI -0.06 to 0.03, p=0.453).Conclusions
The association between maternal asthma and impaired infant lung function diminished in infants whose mothers used ICS during pregnancy.Trial Registration
Australian New Zealand Clinical Trials Registry ACTRN12613000202763.
Date Issued
2026-04-16
Publication Type
Article
Subject(s)
Subjects
Asthma
•
Infant, Newborn
•
Respiratory Function Tests
Language(s)
en
Author(s)
Martins Costa Gomes, Gabriela | |
Collison, Adam M | |
Karmaus, Wilfried J J | |
Da Silva Sena, Carla Rebeca | |
Murphy, Vanessa E | |
Brew, Bronwyn K | |
Grace, Tegan | |
Robinson, Paul D | |
Sly, Peter D | |
Pennell, Craig E | |
Gibson, Peter G | |
Mattes, Joerg |
Additional Credits
Journal
Thorax
Publisher
BMJ Publishing Group
ISSN
1468-3296
0040-6376
Access(Rights)
restricted