Epidemiology and outcomes of bone and joint infections in solid organ transplant recipients.

Publisher DOI
PubMed ID
36031963
Abstract
Bone and joint infection (BJI) epidemiology and outcomes in solid organ transplant recipients (SOTr) remain largely unknown. We aim to describe BJI in a multi-center cohort of SOTr (Swiss Transplant Cohort Study). All consecutive SOTr with BJI (01.05.2008-31.12.2019) were included. A nested case-control study to identify risk factors for BJI was performed. Among 4,482 patients, 61 SOTr with 82 BJI were included, at an incidence of 1.4% (95%CI 1.1-1.7), higher in heart and kidney-pancreas SOTr (Gray's test p<0.01). Although BJI were predominately late events (median of 18.5 months post-SOT), most infections occurred during the first year post-transplant in thoracic SOTr. Diabetic foot osteomyelitis was the most frequent infection (38/82, 46.3%), followed by non-vertebral osteomyelitis (26/82, 31.7%). Pathogens included Gram-positive cocci (70/131, 53.4%), Gram-negative bacilli (34/131, 26.0%), and fungi (9/131, 6.9%). BJI predictors included male gender (OR 2.94, 95% CI 1.26-6.89) and diabetes (OR 2.97, 95% CI 1.34-6.56). Treatment failure was observed in 25.9% (21/81) patients and 1-year mortality post-BJI diagnosis was 14.8% (9/61). BJI remain a rare event in SOTr, associated with subtle clinical presentations, high morbidity and relapses, requiring additional studies in the future.
Date Issued
2022-12
Publication Type
Article
Subject(s)
Subjects
BJI Solid organ transplant recipients bone and joint infection epidemiology
Language(s)
en
Author(s)
Pham, Truong-Thanh
Andrey, Diego O
Stampf, Susanne
Burkhard, Sara H
Tschopp, Johnathan
Ullrich, Kathrin
Strahm, Carol
Schreiber, Peter W
Boillat-Blanco, Noémie
Garzoni, Christian
Khanna, Nina
Manuel, Oriol
Mueller, Nicolas J
Suva, Domizio
van Delden, Christian
Uçkay, Ilker
Neofytos, Dionysios
Additional Credits
Journal
American journal of transplantation
Publisher
Wiley
ISSN
1600-6143
Access(Rights)
metadata.only
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